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2013

Pretorius, E., Vermeulen, N., Bester, J., Lipinski, B., Kell, D.B. (2013): A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy. Toxicol Mech Methods 2013. doi:10.3109/15376516.2012.762082



2012

Funke, C., Schneider, S. A., Berg, D. and Kell, D.B. (2012). Genetics and iron in the systems biology of Parkinson’s disease and some related disorders. NCI, in press. doi:10.1016/j.neuint.2012.11.015

Kell, D. B., Dobson, P. D., Bilsland, E. and Oliver, S. G. (2012). The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so. Drug Discovery Today, in press.

O'Hagan, S., Knowles, J. & Kell, D. B. (2012). Exploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computing. PLoS ONE 7, e48862.

Kell, D.B. (2012) Reviews turn facts into understanding. Nature 490, 37.

Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B. & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of ?rst trimester tissue and changes related to preeclampsia in late pregnancy. Metabolomics (2012) 8:579–597, doi:10.1007/s11306-011-0348-6

Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., Mendes, P. & Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC Systems Biology 6, 73.

Miwa, M., Thompson, P., McNaught, J., Kell, D.B. & Ananiadou, S. (2012) Extracting semantically enriched events from biomedical literature. BMC Bioinformatics 2012, 13:108.

Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B. & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. Mol BioSyst 8, 1760-1774.

Kell D.B. (2012) Large-scale sequestration of carbon via plant roots in natural and agricultural ecosystems: why and how. Phil Trans R Soc 367, 1589-1597.

Davey, H. M., Cross, E. J. M., Davey, C. L., Gkargkas, K., Delneri, D., Hoyle, D. C., Oliver, S. G., Kell, D. B. & Griffith, G. W. (2012). Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals the importance of recycling in maintaining cell viability. Env Microbiol, in press.

Wang, Y., Paszek, P., Horton, C. A., Yue H., White M. R. H., Kell D. B., Muldoon M. R. & Broomhead D. S. (2012). A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation. J. Theoret. Biol., 297, 137-147.

Kell, D.B. (2012). Scientific discovery as a combinatorial optimisation problem: How best to navigate the landscape of possible experiments? BioEssays (online early view).

Pir, P., Gutteridge, A., Wu, J., Rash, B., Kell, D. B., Zhang, N. & Oliver, S. G. (2012). The genetic control of growth rate: a systems biology study in yeast. BMC Sys Bio 6:4



2011

Swainston, N., Smallbone, K., Mendes, P., Kell, D. B. & Paton, N. W. (2011). The SuBliMinaL Toolbox: automating steps in the reconstruction of metabolic networks. Integrative Bioinf 8, 186.

Courtot, M., Juty, N., Knupfer, C., Waltemath, D., Zhukova, A., Drager, A., Dumontier, M., Finney, A., Golebiewski, M., Hastings, J., Hoops, S., Keating, S., Kell, D. B., Kerrien, S., Lawson, J., Lister, A., Lu, J., Machne, R., Mendes, P., Pocock, M., Rodriguez, N., Villeger, A., Wilkinson, D. J., Wimalaratne, S., Laibe, C., Hucka, M. and Le Novere, N. (2011). Controlled vocabularies and semantics in systems biology. Mol Syst Biol 7:543 doi:10.1038/msb.2011.77

Small, B. G., McColl, B. W., Allmendinger, R., Pahle, J., López-Castejón, G., Rothwell, N. J., Knowles, J., Mendes, P., Brough, D., and Kell, D. B. (2011). Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing. Nature Chemical Biology (2011) doi:10.1038/nchembio.689

Lanthaler, K., Bilsland, E., Dobson, P. D., Moss, H. J., Pir, P., Kell, D. B., and Oliver, S. G. (2011). Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. BMC Biology 2011, 9:70

Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W., Winder, C. L., Lanthaler, K., Pir, P., Malys, N., Kell, D.B., Oliver, S. G., Gaskell, S. J. & Beynon, R. J. (2011). Absolute quantification of the glycolytic pathway in yeast: deployment of a complete QconCAT approach.Mol Cell Proteomics 10, M111 007633.

Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C., North, R. A., McCowan, L., Kell, D. B., Baker, P. N. & Kenny, L. C. (2011). Metabolic profiling uncovers a phenotypic signature of Small for Gestational Age in early pregnancy. J Proteome Res 10, 3660-3673.

Kell DB. Carbon dioxide - an age-old problem. FST Journal 2011; 20:22-23.

Kell DB. (2011). Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration. Annals of Botany. doi:10.1093/aob/mcr175

Kell DB, Dobson PD, Oliver SG (2011). Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only. Drug Discovery Today. (2011) 16:15-16 704-714. doi:10.1016/j.drudis.2011.05.010

Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N, Brown N, Knowles J, Halsall A, Haselden JN, Nicholls A, Wilson ID, Kell DB, Goodacre R and The Husermet consortium (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nature Protocols 6:1060-1083.

Flavell, R., de Brito Cruz, C. H., Christie, M., Allen, J., Keller, M., Gilna, P. & Kell, D. B. (2011). Moving forward with biofuels. Nature Outlook Biofuels 474, S44-S48.

Brown, M., Wedge, D., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., Mamas, M. A., Neyses, L. & Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. Bioinformatics 27, 1108-1112.

Nobata, C., Dobson, P., Iqbal, S. A., Mendes, P., Tsujii, J. i., Kell, D. B. & Ananiadou, S. (2011). Mining metabolites: extracting the yeast metabolome from the literature. Metabolomics 7, 94-101.

Patel, Y., Heyward, C. A., White, M. R. H. & Kell, D. B. (2011). Predicting the points of interaction of small molecules in the NF-kappaB pathway. BMC Systems Biology 5, 32.

Kell DB: Understanding the languages of cells. Network modelling in metabolic systems biology and biotechnology: why, how and whither. The Biochemist 2011; 33:4-7.

Wang, Y., Paszek, P., Horton, C. A., Kell, D. B., White, M. R. H., Broomhead, D. S. and Muldoon, M. R. (2011), Interactions among oscillatory pathways in NF- kappa B signalling., BMC Systems Biology 2011, 5:23 DOI:10.1186/1752-0509-5-23 (online version)

Kell D.B.: Metabolites do social networking. Nat Chem Biol 2011; 7:7-8.




2010

Li P, Dada JO, Jameson D, Spasic I, Swainston N, Carroll K, Dunn W, Khan F, Messiha HL, Simeonidis E, Weichart D, Winder C, Broomhead DS, Goble CA, Gaskell SJ, Kell DB, Westerhoff HV, Mendes P, Paton NW: Systematic integration of experimental data and models in systems biology. BMC Bioinformatics 2010; 11:582. (Online version).

Kell, D. B. (2010). Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. Arch Toxicol 577, 825-889. (Online version here)

Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., Lu, C., Swainston, N., Dunn, W. B., Fisher, P., Hull, D., Brown, M., Oshota, O., Stanford, N. J., Kell, D. B., King, R. D., Oliver, S. G., Stevens, R. D. & Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC Systems Biology 4, 145.

Horgan RP, Broadhurst DI, Dunn WB, Brown MC, Heazell AE, Kell DB, Baker PN, Kenny LC: Changes in the metabolic footprint of placental villous explants cultured in different oxygen tensions from placentas of Small for Gestational Age and normal pregnancies. Placenta 2010; 31:893-901.

Rowe W, Wedge DC, Platt M, Kell DB, Knowles J: Predictive models for population performance on real biological fitness landscapes. Bioinformatics 2010; 26:45-52.

Attwood TK, Kell DB, McDermott P, Marsh J, Pettifer S, Thorne D: Utopia Documents: linking scholarly literature with research data. Bioinformatics 2010; 26:i568-574.

Swainston N, Golebiewski M, Messiha H, Malys N, Kania R, Kengne S, Krebs O, Mir S, Sauer-Danzwith H, Smallbone K, Weidemann A, Wittig U, Kell D, Mendes P, Müller W, Paton N, Rojas I: Enzyme kinetics informatics: from instrument to browser. FEBS J 2010; 277:3769–3779.

Kenny LC, Broadhurst DI, Dunn W, Brown M, Francis-McIntyre S, North RA, McGowan L, Roberts C, Cooper GJS, Kell DB, Philip N Baker on behalf of the SCOPE consortium: Robust early pregnancy prediction of later preeclampsia using metabolomic biomarkers. Hypertension 2010; 56:741-749.

Kell, D. B. (2010). Systems microbiology. Microbiol Today 37, 14-15.

Rowe, W., Platt, M., Wedge, D. C., Day, P. J. R., Kell, D. B. & Knowles, J. D. (2010). Convergent evolution to an aptamer observed in small populations on DNA microarrays. Phys Biol 7, 036007.

Ananiadou, S., Pyysalo, S., Tsujii, J. i. & Kell, D. B. (2010). Event extraction for systems biology by text mining the literature. Trends Biotechnol 2010; 28:381-390.

Villéger, A. C., Pettifer, S. R. & Kell, D. B. (2010). Arcadia: a visualization tool for metabolic pathways. Bioinformatics 20, 1470-1.

Rowe, W., Platt, M., Wedge, D., Day, P. J., Kell, D. B. & Knowles, J. (2010). Analysis of a complete DNA-protein affinity landscape. J R Soc Interface 7, 397-408. (Supplementary data)





2009

Wedge, D. C., Das, A., Dost, R., Kettle, J., Madec, M.-B., Morrison, J. J., Grell, M., Kell, D. B., Richardson, T. H., Yeates, S. & Turner, M. L. (2009). Real-time vapour sensing using an OFET - based electronic nose and genetic programming. Sens Act B 143, 365-372.

Attwood, T. K., Kell, D. B., McDermott, P., Marsh, J., Pettifer, S. R. & Thorne, D. (2009). Calling International Rescue: knowledge lost in literature and data landslide! Biochem J. 424, 317-333. See also: Get Utopia Software.

Dunn, W. B., Brown, M., Worton , S. A., Crocker, I. P., Broadhurst, D., Horgan, R., Kenny, L. C., Baker, P. N., Kell, D. B. & Heazell, A. E. P. (2009). Changes in the metabolic footprint of placental explant-conditioned culture medium identifies metabolic disturbances related to hypoxia and pre-eclampsia. Placenta 37, 974-980.

Kell DB: The importance of mathematics in systems biology. Mathematics Today 2009; August issue:167-172.

Williamson, T., Schwartz, J.-M., Kell, D. B. & Stateva, L. (2009). Deterministic mathematical models of the cAMP pathway in Saccharomyces cerevisiae. BMC Systems Biology 3, 70.

Handley, C. M., Hawe, G. I., Kell, D. B. & Popelier, P. L. A. (2009). Optimal construction of a fast and accurate polarisable water potential based on multipole moments trained by machine learning. Phys Chem Chem Phys 11, 6365-6376.

Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., Knowles, J., HUSERMET consortium, Goodacre, R. & Kell, D. B. (2009). Development and performance of a gas chromatography-time-of-flight mass spectrometry analysis for large-scale non-targeted metabolomic studies of human serum. Anal Chem 81, 7038-7046.

Le Novère, N., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., Demir, E., Wegner, K., Aladjem, M., Wimalaratne, S. M., Bergman, F. T., Gauges, R., Ghazal, P., Hideya, K., Li, L., Matsuoka, Y., Villéger, A., Boyd, S. E., Calzone, L., Courtot, M., Dogrusoz, U., Freeman, T., Funahashi, A., Ghosh, S., Jouraku, A., Kim, S., Kolpakov, F., Luna, A., Sahle, S., Schmidt, E., Watterson, S., Wu, G., Goryanin, I., Kell, D. B., Sander, C., Sauro, H., Snoep, J. L., Kohn, K. & Kitano, H. (2009). The systems biology graphical notation. Nat Biotechnol 27, 735-741. Supplementary information.

Kell, D. B. (2009). Journal Club: A systems biologist ponders how disparate ideas can sometimes come together beautifully. Nature 460, 669.

Kell, D. B. (2009). Correspondence - Dormant microbes: time to revive some old ideas, Nature 458, 831.

Jameson, D., Turner, D. A., Ankers, J., Kennedy, S., Ryan, S., Swainston, N., Griffiths, T., Spiller, D. G., Oliver, S. G., White, M. R. H., Kell, D. B. & Paton, N. W. (2009). Information management for high content live cell imaging. BMC Bioinformatics 10, 226.

Platt, M., Rowe, W., Wedge, D. C., Kell, D. B., Knowles, J. & Day, P. J. R. (2009). Aptamer evolution for array-based diagnostics. Anal Biochem, 390, 203-205.

Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L., Francis-McIntyre, S., Begley, P., Carroll, K., Broadhurst, D., Tseng, A., Swainston, N., Spasic, I., Goodacre, R. & Kell, D. B. (2009). Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. Analyst 134, 1322-1332.

Pettifer, S. R., Thorne, D., McDermott, P., Marsh, J., Villéger, A., Kell, D. B. & Attwood, T. K. (2009). Visualising biological data: a semantic approach to tool and database integration. BMC Bioinformatics 10, S19.

Spasić, I., Simeonidis, E., Messiha, H. L., Paton, N. W. & Kell, D. B. (2009). KiPar, a tool for systematic information retrieval regarding parameters for kinetic modelling of yeast metabolic pathways. Bioinformatics 25, 1404-1411.

Kell, D. B. (2009). Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Medical Genomics 2, 2 - doi:10.1186/1755-8794-2-2 One of our most accessed papers! See BMC Medical Genomics: Most accessed articles of the past year, and of all time.

Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Ryan, S., Sillitoe, K., Harper, C. V., Spiller, D. G., Unitt, J. F., Broomhead, D. S., Kell, D. B., Rand, D., Sée, V. & White, M. R. H. (2009). Pulsatile stimulation determines timing and specificity of NF-κ-B-dependent transcription. Science 324, 242-246. Supplementary Information

Das, A., Dost, R., Richardson, T. H., Grell, M., Wedge, D. C., Kell, D. B., Morrison, J. J. & Turner, M. L. (2009). Low cost, portable,fast multiparameter data acquisition system for organic transistor odour sensors. Sens. Act. B 137, 586-591

Kell, D. B. & Dobson, P. D. (2009). The cellular uptake of pharmaceutical drugs is mainly carrier-mediated and is thus an issue not so much of biophysics but of systems biology. In Systems Chemistry, pp. 149-168. Beilstein Institute, Frankfurt

Dobson, P., Lanthaler, K., Oliver, S. G. & Kell, D. B. (2009). Implications of the dominant role of cellular transporters in drug uptake. Curr Top Med Chem 9, 163-184

Platt, M., Rowe, W., Knowles, J., Day, P. J. & Kell, D. B. (2009). Analysis of aptamer sequence-activity relationships. Integr Biol 1, 116-122. DOI: 10.1039/b814892a.

Zelena, E., Dunn, W., Broadhurst, D., Francis-McIntyre, S., Carroll, K., Begley, P., O'Hagan, S., Knowles, J. D., Halsall, A., HUSERMET Consortium, Wilson, I. & Kell, D.B. (2009). Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum. Anal Chem 81, 1357-1364

Wedge, D., Rowe, W., Kell, D. B. & Knowles, J. (2009). In silico modelling of directed evolution: implications for experimental design and stepwise evolution. J Theor Biol, 2009, 131-141

Knight, C.G., Platt, M., Rowe, W., Wedge, D.C., Khan, F., Day, P.J.R., McShea, A., Knowles, J. and Kell, D.B. (2009). Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape. Nucleic Acids Research, 2009, Vol. 37, No. 1 e6 (Supplementary info: 1, 2, 3 & 4 Data: Training Data; Test Sequence Data; Readme.txt)

Dobson, P. D., Patel, Y. & Kell, D. B. (2009). "Metabolite-likeness" as a criterion in the design and selection of pharmaceutical drug libraries. Drug Disc Today, 14, 31-40





2008

Kell, D. B. (2008). Progress being made on standards for use in data sharing. Nature 456, 29

Hull, D., Pettifer, S. R. & Kell, D. B. (2008). Defrosting the digital library: bibliographic tools for the next generation web. PLoS Comput Biol 4, e1000204. doi:10.1371/journal.pcbi.1000204.

Dobson, P. D. & Kell, D. B. (2008). Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov, 7, 205-220. Supplementary Information. Link to journal. . (Request Reprint)

Wedge, D. & Kell, D. B. (2008). Rapid prediction of optimum population size in genetic programming using a novel genotype - fitness correlation. GECCO 2008 (M. Keizer et al., eds), 1315-1322. (Nominated for best paper.)

Farrelly, C., Kell, D. B. & Knowles, J. (2008). Predicting molecular structure using ant colony optimization: a preliminary study. LNCS 5217, 120-131

Herrgård, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Blüthgen, N., Borger, S., Costenoble, R., Heinemann, M., Hucka, M., Le Novère, N., Li, P., Liebermeister, W., Mo, M. L., Oliveira, A. P., Petranovic, D., Pettifer, S., Simeonidis, E., Smallbone, K., Spasić, I., Weichart, D., Brent, R., Broomhead, D. S., Westerhoff, H. V., Kirdar, B., Penttilä, M., Klipp, E., Palsson, B. Ø., Sauer, U., Oliver, S. G., Mendes, P., Nielsen, J. & Kell, D. B. (2008). A consensus yeast metabolic network obtained from a community approach to systems biology. Nature Biotechnol. 26, 1155-1160

Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B. (2008). The landscape adaptive particle swarm optimizer. Applied Soft Computing J 8, 295-304

Yue, H., Brown, M., He, F., Jia, J. & Kell, D. B. (2008). Sensitivity analysis and robust experimental design of a signal transduction pathway system. Int J Chem Kinet 40, 730-741

Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker, I. P., Baker, P. N. & Kell, D. B. (2008). Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. Placenta 29, 691-698

Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W. G., Kenny, L. C. & Kell, D. B. (2008). Metabolic profiling of mammalian serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. J Chromatogr B, 871, 288-298

Li, P., Castrillo, J. I., Velarde, G., Wassink, I., Soiland-Reyes, S., Owen, S., Withers, D., Oinn, T., Pocock, M. R., Goble, C. A., Oliver, S. G. & Kell, D. B. (2008). Performing statistical analyses on quantitative data in Taverna workflows: an example using R and maxdBrowse to identify differentially expressed genes from microarray data. BMC Bioinformatics 9, 334

Kell, D. B. (2008). Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. Preprint (159pp):http://arxiv.org/abs/0808.1371

Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W., Kell, D. B. & Baker, P. N. (2008). Detection and identification of novel metabolomic biomarkers in preeclampsia. Reprod Sci 15, 591-7

Kell, D. B. & Mendes, P. (2008). The markup is the model: reasoning about systems biology models in the Semantic Web era. J Theoret Biol, 252, 538-543

Spasić, I., Schober, D., Sansone, S., Rebholz-Schuhmann, D., Kell, D.B. & Paton, N.W. (2008) Facilitating the development of controlled vocabularies for metabolomics technologies with text mining. BMC Bioinformatics, 9, S5

Lu, H., Dunn, W. B., Shen, H., Kell, D. B. & Liang, Y. (2008). Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS. Trends Anal Chem 27, 215-227

Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Ashworth, J., Cameron, M., Halsall, A., O'Hagan, S., Spasić, I., Tseng, A. & Kell, D. B. (2008). A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. Int J Epidemiol 2007, 1-8

Jayawardhana, B., Kell, D.B. & Rattray, M. (2008) Bayesian inference of the sites of perturbations in metabolic pathways via Markov Chain Monte Carlo. Bioinformatics, doi: 10.1093/bioinformatics/btn1103

Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I. & Hedger, J. N. (2008). Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus Stereum hirsutum with its competitors Coprinus micaceus and Coprinus disseminatus. Metabolomics 4, 52-62

Li, P., Oinn, T., Stoiland, S. & Kell, D. B. (2008). Automated manipulation of systems biology models using libSBML within Taverna workflows. Bioinformatics 24, 287-289

Delneri, D., Hoyle, D. C., Gkargkas, K., Cross, E. J., Rash, B., Zeef, L., Leong, H. S., Davey, H. M., Hayes, A., Kell, D. B., Griffith, G. W. & Oliver, S. G. (2008). Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures. Nat Genet 40, 113-7

Wilkinson, S. J., Benson, N. & Kell, D. B. (2008). Proximate parameter tuning for biochemical networks with uncertain kinetic parameters. Mol Biosyst, 10.1039/b707506e. Enhanced HTML at RSC.

Lüdtke, N., Panzeri, S., Brown, M., Broomhead, D. S., Knowles, J., Montemurro, M. A. & Kell, D. B. (2008). Information-theoretic Sensitivity Analysis: a general method for credit assignment in complex networks. J Roy Soc Interface 5, 223-235





2007

Dunn, W. B., Broadhurst, D. I., Sasalu, D., Buch, M., McDowell, G., Spasić, I., Ellis, D. I., Brooks, N., Kell, D. B. & Neyses, L. (2007). Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate. Metabolomics 3, 413-426. Supplementary information

Smallbone, K., Simeonidis, E., Broomhead, D. S. & Kell, D. B. (2007). Something from nothing: bridging the gap between constraint-based and kinetic modelling. FEBS J 274, 5576-5585

Kell, D. B. (2007). The virtual human: towards a global systems biology of multiscale, distributed biochemical network models. IUBMB Life 59, 689-95

Goodacre, R., Broadhurst, D., Smilde, A., Kristal, B. S., Baker, J. D., Beger, R., Bessant, C., Connor, S., Capuani, G., Craig, A., Ebbels, T., Kell, D. B., Manetti, C., Newton, J., Paternostro, G., Somorjai, R., Sjöström, M., Trygg, J. & Wulfert, F. (2007). Proposed minimum reporting standards for data analysis in metabolomics. Metabolomics 3, 231-241

Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M., Fuller, L. J., Mellon, F. A., Dunn, W. B., Brown, M., Goodacre, R., Kell, D. B., Marvin, M. E., Louis, E. J. & Roberts, I. N. (2007). Metabolic footprinting as a tool for discriminating between brewing yeasts. Yeast 24, 667-679.

Yisu, J., Knowles, J., Hongmei, L., Yizeng, L. & Kell, D. B. (2007).The landscape adaptive particle swarm optimizer. Applied Soft Computing J 8, 295-304.

Kell, D. B. (2007).Metabolomic biomarkers: search, discovery and validation. Exp Rev Mol Diagnost 7, 329-333.

Wedge, D., Gaskell, S. J., Hubbard, S., Kell, D. B., Lau, K. W. & Eyers, C. (2007). Peptide detectability following ESI mass spectrometry: prediction using genetic programming. In GECCO 2007 (ed. D. Thierens et al.), pp. 2219-2225. ACM, New York.

Handl, J., Kell, D. B. & Knowles, J. (2007). Multiobjective optimization in bioinformatics and computational biology. IEEE Trans Comput Biol Bioinformatics 4, 279-292.

Westerhoff, H. V. & Kell, D. B. (2007). The methodologies of systems biology. In Systems biology: philosophical foundations (ed. F. C. Boogerd, F. J. Bruggeman, J.-H. S. Hofmeyr and H. V. Westerhoff), pp. 23-70. Elsevier, Amsterdam.

Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C. J., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., Rash, B., Brown, M., Dunn, W. B., Broadhurst, D., O'Donoghue, K., Hester, S. S., Dunkley, T. P. J., Hart, S. R., Swainston, N., Li, P., Gaskell, S. J., Paton, N. W., Lilley, K. S., Kell, D. B. & Oliver, S. G. (2007). Growth control of the eukaryote cell: a systems biology study in yeast. J. Biol 6, 4. See also commentary. Most accessed article of the year in December 2007

Oinn, T., Li, P., Kell, D. B., Goble, C., Goderis, A., Greenwood, M., Hull, D., Stevens, R., Turi, D. & Zhao, J. (2007). Taverna /myGrid: aligning a workflow system with the life sciences community. In Workflows for e-Science: scientific workflows for Grids (ed. I. J. Taylor, E. Deelman, D. B. Gannon and M. Shields), pp. 300-319. Springer, Guildford

O'Hagan, S., Dunn, W. B., Broadhurst, D., Williams, R., Ashworth, J. A., Cameron, M., Knowles, J. & Kell, D. B. (2007). Closed-loop, multi-objective optimisation of two-dimensional gas chromatography (GCxGC-tof-MS) for serum metabolomics. Anal Chem 79, 464-476





2006

Broadhurst, D. & Kell, D. B. (2006). Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2, 171-196; DOI: 10.1007/s11306-006-0037-z

Ananiadou, S., Kell, D. B. & Tsujii, J.-i. (2006). Text Mining and its potential applications in Systems Biology. T rends Biotechnol 24, 571-579

Kell, D.B. (2006) Systems biology, metabolic modelling and metabolomics in drug discovery and development Drug Discovery Today, 11, 1085-1092.

Shen, H., Nelson, G., Nelson, D.E., Kennedy, S., Spiller, D.G., Griffiths, T., Paton, N., Oliver, S.G., White, M.R.H., Kell, D.B. (2006) Automated tracking of gene expression in individual cells and cell compartments Journal of the Royal Society Interface, 3, 787-794. [web site]

Yue, H., Brown, M., Knowles, J., Wang, H., Broomhead, D.S. & Kell, D.B. (2006) Insights into the behaviour of systems biology models from dynamic sensitivity and identifiability analysis: a case study of an NF-κ -B signalling pathway. Molecular BioSystems, 2, 640-649.

Spasic, I., Dunn, W., Velarde, G., Tseng, A., Jenkins, H., Hardy, N.W., Oliver, S.G. & Kell, D.B. (2006) MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics. BMC Bioinformatics, 7, 281. [web site]

Shen, H., Nelson, G., Kennedy, S., Nelson, D., Johnson, J., Spiller, D., White, M.R.H. & Kell, D.B. (2006) Automatic tracking of biological cells and compartments using particle filters and active contours. Chemometrics and Intelligent Laboratory Systems 82, 276 282. [web site]

Underwood, B.R., Broadhurst, D., Dunn, W.B., Ellis, D.I., Michell, A.W., Vacher, C., Mosedale, D.E., Kell, D.B., Barker, R., Grainger, D.J. & Rubinsztein, D.C. (2006) Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. Brain 129, 877-886.

Kell, D.B. & Knowles, J.D. (2006) The role of modeling in systems biology. In System modeling in cellular biology: from concepts to nuts and bolts (ed. Z. Szallasi, J. Stelling and V. Periwal), pp. 3-18. MIT Press, Cambridge.

Kell, D.B. (2006) Metabolomics, modelling and machine learning in systems biology towards an understanding of the languages of cells. The 2005 Theodor Bcher lecture. The FEBS Journal 273, 873-894.

Mukamolova, G.V., Murzin, A.G., Salina, E.G., Demina, G.R., Kell, D.B., Kaprelyants, A.S. & Young, M. (2006) Muralytic activity of Micrococcus luteus Rpf and its relationship to physiological activity in promoting bacterial growth and resuscitation. Molecular Microbiology 59, 84-98.







2005

Kenny, L.C., Dunn, W.B., Ellis, D.I., Myers, J., Baker, P.N., The GOPEC Consortium & Kell, D.B. (2005). Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. Metabolomics, 1(3), 227-234. DOI: 10.1007/s11306-005-0003-1.

Ihekwaba, A.E.C., Broomhead, D.S., Grimley, R., Benson, N., White, M.R.H. & Kell, D.B. (2005). Synergistic control of oscillations in the NF-κB signalling pathway. IEE Systems Biology, 152, 153-160.

Vaidyanathan, S., Jones, D., Broadhurst, D.I., Ellis, J., Jenkins, T., Dunn, W.B., Hayes, A., Burton, N., Oliver, S.G., Kell, D.B. & Goodacre, R. (2005). A laser desorption ionisation mass spectrometry approach for high throughput metabolomics. Metabolomics, 1(3), 243-250. DOI: 10.1007/s11306-005-0007-x.

Hancock, D., Wilson, M., Velarde, G., Morrison, N., Hayes, A., Hulme, H., Wood, A.J., Nashar, K., Kell, D.B. & Brass, A. (2005) maxdLoad2 and maxdBrowse:standards-compliant tools for microarray experimental annotation, data management and dissemination. BMC Bioinformatics, 6, 264.

Catchpole, G.S., Beckmann, M., Enot, D.P., Mondhe, M., Zywicki, B., Taylor, J., Hardy, N., Smith, A., King, R.D., Kell, D.B., Fiehn, O. & Draper, J. (2005) Hierarchical metabolomics demonstrates substantial compositional similarity between genetically modified and conventional potato crops. Proc Natl Acad Sci U S A 102, 14458-62.

Handl, J., Knowles, J. & Kell, D.B. (2005) Computational cluster validation in post-genomic data analysis. Bioinformatics, 21, 3201-3212.

Kell, D.B., Brown, M., Davey, H.M., Dunn, W.B., Spasić, I. & Oliver, S.G. (2005) Metabolic footprinting and systems biology: the medium is the message. Nat Rev Microbiol, 3, 557-565.

Kell, D.B. (2005) Metabolomics, machine learning and modelling: towards an understanding of the language of cells. Biochem Soc Trans 33, 520-524.

Pritchard, L., Corne, D., Kell, D.B., Rowland, J. & Winson, M. (2005) A general model of error-prone PCR. Journal of Theoretical Biology 234, 497509.

Johnson, H.E., Merry, R.J., Davies, D.R., Kell, D.B., Theodorou, M.K. & Griffith, G.W. (2005) Vacuum packing: a model system for laboratory-scale silage fermentations. J Appl Microbiol 98, 106-113.

Brown, M., Dunn, W.B., Ellis, D.I., Goodacre, R., Handl, J., Knowles, J.D., O'Hagan, S., Spasić, I. & Kell, D.B. (2005) A metabolome pipeline: from concept to data to knowledge. Metabolomics 1(1), 39-51.

O'Hagan, S., Dunn, W.B., Brown, M., Knowles, J.D. & Kell, D.B. (2005) Closed-loop, multiobjective optimization of analytical instrumentation: gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. Anal. Chem 77, 290-303.






2004

Jenkins, H., Hardy, N., Beckmann, M., Draper, J., Smith, A.R., Taylor, J., Fiehn, O., Goodacre, R., Bino, R.J., Hall, R., Kopka, J., Lane, G.A., Lange, B.M., Liu, J.R., Mendes, P., Nikolau, B.J., Oliver, S.G., Paton, N.W., Rhee, S., Roessner-Tunali, U., Saito, K., Smedsgaard, J., Sumner, L.W., Wang, T., Walsh, S., Syrkin Wurtele, E. & Kell, D.B. (2004) A proposed framework for the description of plant metabolomics experiments and their results. Nature Biotechnol. 22(12), 1601-1606.

Ihekwaba, A., Broomhead, D.S., Grimley, R., Benson, N. & Kell, D.B. (2004) Sensitivity analysis of parameters controlling oscillatory signalling in the NF-κB pathway: the roles of IKK and IkBa. Systems Biology 1, 93-103.

Zhao, H., Kassama, Y., Young, M., Kell, D.B. & Goodacre, R. (2004) Differentiation of Micromonospora isolates from a coastal sediment in Wales based on Fourier transform infrared spectroscopy, 16S rDNA sequence analysis, and the amplified fragment length polymorphism technique. Appl. Env. Microbiol. 70, 6619-8827.

Nelson, D. E., Ihekwaba, A. E. C., Elliott, M. , Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., Edwards, S. W., McDowell, H. P., Unitt, J. F., Sullivan, E., Grimley, R., Benson, N., Broomhead, D., Kell, D. B. & White, M. R. H. (2004) Oscillations in NF-B Signaling Control the Dynamics of Gene Expression. Science 306, 704-708.

Allen, J., Davey, H.M., Broadhurst, D., Rowland, J.J., Oliver, S.G. & Kell, D.B. (2004) Discrimination of modes of action of antifungal substances by use of metabolic footprinting. Applied and Environmental Microbiology 70(10), 61576165.

Vaidyanathan, S., Kell, D.B. & Goodacre, R. (2004) Selective detection of proteins in mixtures using electrospray ionization mass spectrometry: influence of instrumental settings and implications for proteomics. Anal. Chem. 76, 5024-5032.

Kell, D. B., Woodward, A. M., Davies, E. A., Todd, R. W., Evans, M. F., Rowland, J. J. (2004) Nonlinear dielectric spectroscopy of biological systems: principles and applications. Nonlinear Phenomena in Complex Liquids, Kluwer Academic Publishers, 335-344.

Kell, D. B. (2004) Metabolomics and systems biology: making sense of the soup. Current Opinion in Microbiology 7(3), 296-307.

Woodward, A. M., Rowland, J. J. & Kell, D. B. (2004) Fast automatic registration of images using the phase of a complex wavelet transform: application to proteome gels. Analyst 129, 542-552.

White, T. A. & Kell, D. B. (2004) Comparative genomic assessment of novel broad-spectrum targets for antibacterial drugs. Comp. Func. Genomics 5, 304-327.

Goodacre, R., Vaidyanathan, S., Dunn, W.B., Harrigan, G.G. & Kell, D.B. (2004) Metabolomics by numbers: acquiring and understanding global metabolite data. Trends. Biotechnol. 22, 245-252.

Johnson, H.E., Broadhurst, D., Kell, D.B., Theodorou, M.K., Merry, R.J. & Griffith, G.W. (2004) High-Throughput Metabolic Fingerprinting of Legume Silage Fermentations via Fourier Transform Infrared Spectroscopy and Chemometrics. Appl. Env.Microbiol. 70, 15831592.

Twist, C. R., Winson, M. K., Rowland, J. J. & Kell, D. B. (2004) SNP detection using nanomolar nucleotides and single molecule fluorescence. Anal. Biochem. 327, 35-44.

King, R.D., Whelan, K.E., Jones, F.M., Reiser, P.G.K., Bryant, C.H., Muggleton, S.H., Kell, D.B. & Oliver, S.G. (2004) Functional genomic hypothesis generation and experimentation by a robot scientist. Nature 427, 247-252. Pubmed abstract.

Kell, D.B. & Oliver, S.G. (2004) Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era. Bioessays 26, 99-105.






2003

Oates, M. J., Corne, D. W. & Kell, D. B. (2003). The bimodal feature at large population sizes and high selection pressure: implications for directed evolution. In Recent advances in simulated evolution and learning (ed. K. C. Tan, M. H. Lim, X. Yao and L. Wang), pp. 215-240. World Scientific, Singapore.

Vaidyanathan, S., Broadhurst, D. I., Kell, D. B. & Goodacre, R. (2003) Explanatory optimisation of protein mass spectrometry via genetic search. Anal. Chem. 75, 6679-6686.

Kell, D. B., Mukamolova, G. V., Finan, C. L., Zhao, H., Goodacre, R., Kaprelyants, A. S. & Young, M. (2003) Resuscitation of 'uncultured' microorganisms. In Microbial diversity and bioprospecting (ed. A. T. Bull), pp. 100-108. American Society for Microbiology, Washington, DC.

Mukamolova, G. V., Kaprelyants, A. S., Kell, D. B. & Young, M. (2003) Adoption of the transiently non-culturable state - a bacterial survival strategy? Adv. Micr. Physiol. 47, 65-129.

Allen, J. K., Davey, H. M., Broadhurst, D., Heald, J. K., Rowland, J. J., Oliver, S. G. & Kell, D. B. (2003) High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nature Biotechnol. 21, 692-696.

Taylor, C. F., Paton, N. W., Garwood, K. L., Kirby, P. D., Stead, D. A., Yin, Z., Deutsch, E. W., Selway, L., Walker, J., RibaGarcia, I., Mohammed, S., Deery, M. J., Howard, J. A., Dunkley, T., Aebersold, R., Kell, D. B., Lilley, K. S., Roepstorff, P., Yates, J. R., Brass, A., Brown, A. J. P., Cash, P., Gaskell, S. J., Hubbard, S. J. & Oliver, S. G. (2003) A systematic approach to modelling capturing and disseminating proteomics experimental data. Nat Biotechnol 21, 247-254.

Goodacre, R. & Kell, D. B. (2003) Evolutionary computation for the interpretation of metabolome data. In Metabolic profiling: its role in biomarker discovery and gene function analysis (ed. G. G. Harrigan and R. Goodacre), pp. 239-256. Kluwer Academic Publishers, Boston.

Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Landscape State Machines: tools for evolutionary algorithm performance analyses and landscape/algorithm mapping. In Evoworkshops 2003, vol. LNCS 2611 (ed. S. Cagnoni, et al.), pp. 187-198. Springer, Berlin.

Corne, D. W., Oates, M. J. & Kell, D. B. (2003) Fitness gains and mutation patterns: deriving mutation rates by exploiting landscape data. In Foundations of Genetic Algorithms 7 (ed. K. A. De Jong, R. Poli and J. E. Rowe), pp. 347-364. Morgan Kaufmann, Amsterdam.

Kaderbhai, N. N., Broadhurst, D. I., Ellis, D. I., Goodacre, R. & Kell, D. B. (2003) Functional genomics via metabolic footprinting: Monitoring metabolite secretion by Escherichia coli tryptophan metabolism mutants using FT-IR and direct injection electrospray mass spectrometry. Comp. Func. Genomics 4, 376-391.






2002

Goodacre, R., Vaidyanathan, S., Bianchi, G. & Kell, D. B. (2002) Metabolic profiling using direct infusion electrospray ionisation mass spectrometry for the characterisation of olive oils. Analyst 127, 1457-1462. Abstract.

Hesketh, A. R., Chandra, G., Shaw, A. D., Rowland, J. J., Kell, D. B., Bibb, M.J. & Chater, K. F. (2002) Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolor. Mol. Microbiol. 46, 917-932. Abstract.

Kell, D. B. (2002) Genotype-phenotype mapping: genes as computer programs. Trends Genet 18, 555-9. Abstract.

Mukamolova, G. V., Turapov, O. A., Young, D. I., Kaprelyants, A. S., Kell, D. B. & Young, M. (2002) A family of autocrine growth factors in Mycobacterium tuberculosis. Mol. Microbiol. 46, 623-635. Abstract.

Mukamolova, G. V., Turapov, O. A., Kazaryan, K., Telkov, M., Kaprelyants, A. S., Kell, D. B. & Young, M. (2002) The rpf gene of Micrococcus luteus encodes an essential secreted growth factor. Mol. Microbiol. 46, 611-621. Abstract.

Corne, D.W., Oates, M.J. & Kell, D.B. (2002) On fitness distributions and expected fitness gain of mutation rates in parallel evolutionary algorithms. In Parallel Problem Solving from Nature - PPSN VII. (eds. J.J. Merelo Guervós, P. Adamidis, H.-G. Beyer, J.-L. Fernández-Villacañas & H.-P. Schwefel) 132-141 (Springer, Berlin; 2002).

Kell, D.B. (2002) Metabolomics and machine learning: explanatory analysis of complex metabolome data using genetic programming to produce simple, robust rules. Mol. Biol. Rep. 29, 237-242.

Groeneveld, P., Rolley, N., Kell, D.B., Kelly, S.L. & Kelly, D.E. (2002) Metabolic control analysis and engineering of the yeast sterol biosynthetic pathway. Mol. Biol. Rep. 29, 27-29.

Pritchard, L. & Kell, D.B. (2002) Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. Eur. J. Biochem. 269, 3894-3904.

Lamb, D.C., Skaug, T., Song, H.L., Jackson, C.J., Podust, L.M., Waterman, M.R., Kell, D.B., Kelly, D.E. & Kelly, S.L. (2002) The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2). J. Biol. Chem. 277, 24000-5.

Vaidyanathan, S., Winder, C.L., Wade, S.C., Kell, D.B. & Goodacre, R. (2002) Sample preparation in matrix-assisted laser desorption ionization mass spectrometry of whole bacterial cells and the detection of high mass (>20 kDa) proteins. Rapid Comm. Mass Spectrom. 16:1276-1286.

Ellis, D. I., Broadhurst, D., Kell, D.B, Rowland, J.J. & Goodacre, R. (2002) Rapid and quantitative detection of the microbial spoilage of meat using Fourier-Transform infrared spectroscopy and machine learning. Appl. Env. Microbiol. 68, 2822-2888. Abstract Pubmed. Abstract ASM. Full text at ASM.

McGovern, A.C., Broadhurst, D., Taylor, J., Gilbert, R.J.,Winson, M.K., Kaderbhai, N., Smal, D.A., Rowland, J.J., Kell, D.B. and Goodacre, R. (2002) Monitoring of complex industrial bioprocesses for metabolite concentrations using modern spectroscopies and machine learning: application to gibberellic acid production. Biotechnol. Bioeng. 78, 527-538.

Shleeva, M.O., Bagramyan, K., Telkov, M.V., Mukamolova, G.V., Young, M., Kell, D.B. and Kaprelyants, A.S. (2002) Formation and resuscitation of "non-culturable" cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase. Microbiology 148, 1581-1591. Abstract. Full text at SGM.

Kell, D. B. (2002) Defence against the flood: a solution to the data mining and predictive modelling challenges of today. Bioinformatics World (part of Scientific Computing News) Issue 1, 16-18. manuscript

Day, J.P., Kell, D.B. & Griffith, G.W. (2002) Differentiation of Phytophthora infestans sporangia from other airborne biological particles by flow cytometry. Appl. Env. Microbiol. 68, 37-45. Abstract. Full text at AEM.

Vaidyanathan S., Kell D.B. & Goodacre R. (2002) Flow-injection electrospray ionization mass spectrometry of crude cell extracts for high-throughput bacterial identification. J Am Soc Mass Spectrom 13(2), 118-128






2001

Reiser P, King RD, Kell DB, Muggleton SH, Bryant CH, Oliver SG (2001) Developing a logical model for yeast metabolism. Electronic Trans. Artif. Intell. 5, 223-244. preprint; as published

Bryant CH, Muggleton SH, Oliver SG, Kell DB, Reiser P, King RD (2001) Combining active inductive programming, active learning and robotics to discover the function of genes. Electronic Trans. Artif. Intell., 5, 1-36. preprint; final

Woodward, A.M., Kaderbhai, N., Kaderbhai, M., Shaw, A.D., Rowland, J.J. & Kell, D.B. (2001) Histometrics: improvement of the dynamic range of fluorescently stained proteins resolved in electrophoretic gels using hyperspectral imaging. Proteomics 1, 1351-1358.

Vaidyanathan, S., Rowland, J.J., Kell, D.B. & Goodacre, R. (2001) Discrimination of aerobic endospore-forming bacteria via electrospray ionization mass spectrometry of whole cell suspensions. Anal. Chem. 73, 4134-4144. Abstract.

Kell, D.B., Darby, R.M. & Draper, J. (2001) Genomic computing: explanatory analysis of plant expression profiling data using machine learning. Plant Physiology 126, 943.951. Abstract. Full paper at Plant Physiology.

Weichart, D.H. & Kell, D.B. (2001) Characterization of an autostimulatory substance produced by Escherichia coli. Microbiology 147, 1875-1885. Abstract. Full text at SGM .

Bianchi, G., Giansante, L., Shaw, A.D. & Kell, D.B. (2001) Chemometric criteria for the characterisation of Italian DOP olive oils from their metabolic profiles. Eur. J. Lipid. Sci. Technol. 103, 141-150.

Mendes, P. & Kell, D.B. (2001) MEG (Model Extender for Gepasi): a program for the modelling of complex, heterogeneous, cellular systems. Bioinformatics 17, 288-289. Abstract.

Clegg, J., Kell, D., Knull, H., Welch, G.R., Wilson, J. (2001) Macromolecular interactions: tracing the roots. Trends Biochem. Sci 26, 91. Abstract.

Raamsdonk, L. M., Teusink, B., Broadhurst, D., Zhang, N., Hayes, A., Walsh, M., Berden, J. A., Brindle, K. M., Kell, D. B., Rowland, J. J., Westerhoff, H. V., van Dam, K. & Oliver, S. G. (2001) A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nature Biotechnology 19, 45-50. Abstract.

Yardley, J., Kell, D.B., Barrett, J. & Davey, C.L. (2001) On-line, real-time measurements of cellular biomass using dielectric spectroscopy. Biotechnol. Genet. Eng. Rev. 17, 3-35.






2000

Biketov, S., Mukamolova, G. V., Potapov, V., Gilenkov, E., Vostroknutova, G., Kell, D. B., Young, M. & Kaprelyants, A. S. (2000) Culturability of Mycobacterium tuberculosis cells isolated from murine macrophages: a bacterial growth factor promotes recovery. FEMS Immunol. Med. Microbiol. 29, 233-240. Abstract.

Johnson, H.E., Gilbert, R.J., Winson, M.K., Goodacre, R., Smith, A.R., Rowland, J.J., Hall, M.A. & Kell, D.B. (2000) Explanatory analysis of the metabolome using genetic programming of simple, interpretable rules. Genetic Programming and Evolvable Machines 1, 243-258.

Barer M., Bogosian G., Kell D. & Williams, H. (2000) Resuscitating a logical approach to viability in the face of an "eastern wind" ASM News 66, 381-382. [Letter]

Wixon, J. & Kell, D.B. (2000) Website review - The Kyoto Encyclopedia of Genes and Genomes - KEGG - http://www.genome.ad.jp/kegg. Yeast 17, 48-55.

Gilbert, R. J., Rowland, J. J. & Kell, D. B. (2000) Genomic computing: explanatory modelling for functional genomics. In Proceedings of the Genetic and Evolutionary Computation Conference (GECCO-2000) (ed. D. Whitley, D. Goldberg, E. Cantú-Paz, L. Spector, I. Parmee and H.-G. Beyer), pp. 551-557. Morgan Kaufmann, San Francisco. pdf version of ms here.

Davey, H. M., and Kell, D. B. (2000) A portable flow cytometer for the detection and identification of microorganisms. In: Rapid Methods for Monitoring the Environment for Biological Hazards, Eds. P. J. Stopa and M. A. Bartoszcze, Kluwer Academic Publishers, Dordrecht, 159-167.

Goodacre, R., Burton, R., Kaderbhai, N, Timmins, É.M., Woodward, A., Rooney, P.J. & Kell, D.B. (2000) Intelligent systems for the characterisation of microorganisms from hyperspectral data. In Rapid Methods for the Analysis of Biological Materials in the Environment. Eds. P.J. Stopa & M.A. Bartoszcze, Kluwer Academic Publishers, Dordrecht, 111-136.

Kaprelyants, A. S., Mukamolova, G. V., Votyakova, T. V., Davey, H. M., and Kell, D. B. (2000) Dormancy in non-sporulating bacteria: its significance for environmental monitoring. Rapid Methods for Monitoring the Environment for Biological Hazards, P. J. Stopa and M. A. Bartoszcze, eds., Kluwer Academic Publishers, Dordrecht, 49-65.

Yardley, J.E., Todd, R.W., Nicholson, D.J., Barrett, J., Kell, D.B. & Davey, C.L. (2000) Correction of the influence of baseline artefacts and electrode polarisation on dielectric spectra. Bioelectrochem. Bioenerg. 51, 53-65. Abstract.

Kell, D.B. & Young, M. (2000) Bacterial dormancy and culturability: the role of autocrine growth factors. Curr. Opin. Microbiol. 3, 238-243.

Kell, D.B. (2000) Screen idols - faster, smaller, cheaper and smarter. [meeting report] Trends Biotechnol. 18, 186-187. Journal ref.

Woodward, A.M., Davies, E.A., Denyer, S., Olliff, C. & Kell, D.B. (2000) Non-linear dielectric spectroscopy: antifouling and stabilisation of electrodes by a polymer coating. Bioelectrochemistry 51, 13-20. Abstract.

Davies, Z.S., Gilbert, R.J., Merry, R.J., Kell, D.B., Theodorou, M.K. & Griffith, G.W. (2000) Efficient improvement of silage additives using genetic algorithms. Appl. Env. Microbiol. 66, 1435-1443. Journal abstract. Pubmed abstract.

Kell, D.B. & King, R.D. (2000) On the optimization of classes for the assignment of unidentified reading frames in functional genomics programmes: the need for machine learning. Trends Biotechnol. 18, 93-98. Journal abstract. Pubmed abstract.

Davies, E., Woodward, A.M. & Kell, D.B. (2000) The use of nonlinear dielectric spectroscopy to monitor the bioelectromagnetic effects of a weak pulsed magnetic field in real time. Bioelectromagnetics 21, 25-33. 30

Goodacre, R., Shann, B., Gilbert, R.J., Timmins, É.M., McGovern, A., Alsberg, B.K., Kell, D.B. & Logan, N.A. (2000) The detection of the dipicolinic acid biomarker in Bacillus spores using Curie-point pyrolysis mass spectrometry and Fourier-transform infrared spectroscopy. Anal. Chem. 72, 119-127. Journal abstract. Pubmed abstract.

Shaw, A.D., Winson, M.K., Woodward, A.M., McGovern, A., Davey, H.M., Kaderbhai, N., Broadhurst, D.I., Gilbert, R.J., Taylor, J., Timmins, É.M., Alsberg, B.K., Rowland, J.J., Goodacre, R. & Kell, D.B. (2000) Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics. Adv. Biochem. Eng. 66, 83-113. Abstract.






1999

Kell, D.B. & Mendes, P. (1999) Snapshots of systems - metabolic control analysis and biotechnology in the post-genomic era. In Technological and Medical Implications of Metabolic Control Analysis (A. Cornish-Bowden and M.L.Cárdenas, ed.) pp. 3-25. Kluwer Academic Publishers, Dordrecht. Ms available in Postscript or pdf versions. See also a draft (pre-meeting) web version .

Shaw, A.D., Kaderbhai, N., Jones, A., Woodward, A.M., Goodacre, R., Rowland, J.J. & Kell, D.B. (1999) Non-invasive, on-line monitoring of the biotransformation by yeast of glucose to ethanol using dispersive Raman spectroscopy and chemometrics. Appl. Spectroscopy. 53, 1419-1428. WoS abstract.

Vlahov, G., Shaw, A.D. & Kell, D.B. (1999) Use of 13C NMR DEPT pulse sequence and multivariate analysis to discriminate olive oil cultivars. J. Amer. Oil Chemists Soc., 76, 1223-1231.

Mukamolova, G.V., Kormer, S.S., Kell, D.B. & Kaprelyants, A.S. (1999) Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor. Arch.Microbiol. 172, 9-14. Abstract.

McGovern, A.C., Ernill, R., Kara, B.V., Kell, D.B. & Goodacre, R. (1999) Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to face="Symbol">a2-interferon production. J. Biotechnol. 72, 157-167. Abstract.

Goodacre, R. Heald, J.K. & Kell, D.B. (1999) Characterisation of intact microorganisms using electrospray ionisation mass spectrometry. FEMS Microbiology Letters 176, 17-24.

Woodward, A.M., Gilbert, R.J. & Kell, D.B. (1999) Genetic programming as an analytical tool for non-linear dielectric spectroscopy. Bioelectrochem. Bioenerg. 48, 389-396. Abstract.

Gilbert, R.J., Johnson, H.E., Winson, M.K., Rowland, J.J., Goodacre, R., Smith, A.R., Hall, M.A. & Kell, D. B. (1999) Genetic programming as an analytical tool for metabolome data. Langdon, W.B., Poli, R., Nodin, P. & Fogarty, T. (eds) Late-breaking papers of EuroGP-99, pp. 23-33.

Davies, E., Olliff, C., Wright, I., Woodward, A. & Kell, D.B. (1999) A weak pulsed magnetic field affects adenine nucleotide oscillations and related parameters in aggregating Dictyostelium discoideum amoebae. Bioelectrochem. Bioenerg. 48, 149-162.

Davey, H.M., Kaprelyants, A.S., Weichart, D.H. and Kell, D.B. (1999) Approaches to the estimation of microbial viability using flow cytometry. In: Current Protocols in Cytometry: Volume 11 Microbial Cytometry, pp. 11.3.1-11.3.20 . Robinson, J.P. (Ed.) Wiley, New York.

Kaprelyants, A.S., Mukamolova, G.V., Kormer, S.S., Weichart, D.H., Young, M. & Kell, D.B. (1999) Intercellular signalling and the multiplication of prokaryotes: bacterial cytokines. Symp. Soc. Gen. Microbiol. 57, 33-69.

Kell, D.B. (1999) Screensavers: trends in high-throughput analysis [meeting report]. Trends in Biotechnol. 17, 89-91.

Kell, D.B. (1999) Nonviable and nonculturable [letter]. ASM News 65(1), 1.

Davey H.M., Jones A., Shaw A.D. and Kell D.B. (1999) Variable selection and multivariate methods for the identification of microorganisms by flow cytometry. Cytometry 35, 162-168. Abstract






1998

Mendes, P. & Kell, D.B. (1998) Nonlinear optimisation of metabolic pathways: applications to metabolic engineering and parameter estimation. Bioinformatics 14, 869-883. Abstract. Abstract at journal with link to pdf.

Goshawk, J.A., Binding, D.M., Kell, D.B. & Goodacre, R. (1998) Rheological phenomena occurring during the shearing flow of mayonnaise. J. Rheology 42, 1537-1553. Abstract at AIP with link to pdf.

Kell, D.B. (1998) From code to mode for orphan genes. [Meeting report]. Trends Biotechnol. 16, 491-493. Abstract.

Alsberg, B.K., Kell, D.B. & Goodacre, R. (1998) Variable selection in discriminant partial least squares analysis. Anal. Chem., 70, 4126-4133.

Davey, C.L. & Kell, D.B. (1998) The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements. II. reduction in the contribution of electrode polarisation to dielectric spectra using a two-frequency method. Bioelectrochem. Bioenerg. 46, 105-114.

Davey, C.L. & Kell, D.B. (1998) The influence of electrode polarisation on dielectric spectra, with special reference to capacitive biomass measurements. I. quantifying the effects on electrode polarisation of factors likely to occur during fermentations. Bioelectrochem. Bioenerg. 46, 91-103.

Mendes, P. & Kell, D.B. (1998) Numerical optimisation and simulation for rational metabolic engineering. In BioThermoKinetics in the post-genomic era (eds Larsson, C., Påhlman, I.-L. & Gustafsson, L.) Chalmers Reproservice, Göteborg, pp. 345-349. Full paper.

Barer, M. R., Karelyants, A. S., Weichart, D. H., Harwood, C. R. & Kell, D. B. (1998) Microbial stress and culturability: conceptual and operational domains. Microbiology 144, 2009-2010.

Taylor, J., Rowland, J.J. & Kell, D.B. (1998) Genetic programming applied to the rapid spectroscopic analysis of biological samples. In Koza, JR (ed) Late-breaking papers at the Genetic Programming 1998 Conference, University of Wisconsin, July 22-25 1998. Omni Press, Madison.

Taylor, J., Rowland, J.J., Goodacre, R., Gilbert, R.J., Winson, M.K. & Kell, D.B. (1998) Genetic programming in the interpretation of Fourier transform infrared spectra: quantification of metabolites of pharmaceutical importance. In (Koza, J.R., Banzhaf, W., Chellapilla, K., Deb, K., Dorigo, M., Fogel, D.B., Garzon, M.H., Goldberg, D.E., Iba, H. & Riolo, R.L., eds.) Genetic Programming 1998: Proceedings of the Third Annual Conference, Madison, WI. (Morgan Kaufmann, San Francisco, CA, pub). pp. 377-380.

Gilbert, R.J., Goodacre, R., Shann, B., Taylor, J., Rowland, J.J. & Kell, D.B. (1998) Genetic programing-based variable selection for high-dimensional data. In (Koza, J.R., Banzhaf, W., Chellapilla, K., Deb, K., Dorigo, M., Fogel, D.B., Garzon, M.H., Goldberg, D.E., Iba, H. & Riolo, R.L., eds.) Genetic Programming 1998: Proceedings of the Third Annual Conference, Madison, WI. (Morgan Kaufmann, San Francisco, CA, pub.). pp. 109-115.

Oliver, S.G., Winson, M.K., Kell, D.B. & Baganz, F. (1998) Systematic functional analysis of the yeast genome. Trends Biotechnol. 16, 373-378. Abstract. Manuscript in Postscript. Web version at Tibtech

Mukamolova, G.V., Kaprelyants, A.S., Young, D.I., Young, M. & Kell, D.B. (1998) A bacterial cytokine. Proc. Natl. Acad. Sci. 95, 8916-8921. PubMed abstract. Abstract at PNAS with link to pdf. Full pdf version freely available at PubMedCentral.

Woodward, A.M., Alsberg, B.K & Kell, D.B. (1998) The effect of heteroscedastic noise on the modelling of frequency domain data. Chemometr. Intell. Lab. Syst. 40, 101- 107

Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. & Kell, D.B. (1998) Variable selection in wavelet regression models. Analytica Chimica Acta, 368, 29- 44.

Jones, A., Young, D., Taylor, J., Kell, D.B. & Rowland, J.J. (1998) Quantification of microbial productivity via multi-angle light scattering and supervised learning. Biotechnol. Bioeng., 59, 131-143. Abstract.

Winson, M.K., Kaderbhai, N., Jones, A., Alsberg, B.K., Woodward, A.M., Shaw, A.D., Goodacre, R., Rowland, J.J., Kell, D.B., Todd, M. & Rudd, B.A.M. (1998) Metabolic microscopy: novel approaches to high-throughput screening in strain development and fermentation analysis using diffuse reflectance FT-IR and dispersive Raman spectroscopy with chemometrics. In (Dixon, G.K., Major, J.S. & Rice, M.J., eds) Challenges and issues in high throughput screening: a pharmaceutical and agrochemical industry perspective, pp. 151-152. SCI, London.

Kell, D.B., Kaprelyants, A.S., Weichart, D.H., Harwood, C.L. & Barer, M.R. (1998) Viability and activity in readily culturable bacteria: a review and discussion of the practical issues. Antonie van Leeuwenhoek 73, 169-187. Abstract.

Goodacre, R., Timmins, É.M., Burton, R., Kaderbhai, N, Woodward, A., Kell, D.B. & Rooney, P.J. (1998) Rapid identification of urinary tract infection bacteria using hyperspectral, whole organism fingerprinting and artificial neural networks. Microbiology 144, 1157- 1170. PubMed abstract. Abstract at Microbiology with link to pdf.

Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Rapid analysis of microbial systems using vibrational spectroscopy and supervised learning methods: application to the discriminatin betweenmethicillin-resistant and methicillin-susceptible Staphylococcus aureus. In Infrared Spectroscopy: New Tool in Medicine. Proc. SPIE 3257, 220-229.

Kell, D.B. & Kaprelyants, A.S. (1998) Are many microbial secondary metabolites really pheromones with important physiological functions, a knowledge of which could guide discovery programmes? Dormancy, differentiation, social resuscitation and pheromone production in nonsporulating bacteria. In Marine microorganism: research issues for biotechnology. Proc. US/EC Workshop on Marine Microorganisms, pp. 87-92. Publ. European Commission, Brussels.

Kell, D.B., Winson, M., Goodacre, R., Alsberg, B., Jones, A., Woodward, A. & Rowland, J. (1998) DRASTIC (Diffuse Reluctance Absorbance SpectroscopyTaking in Chemometrics): a rapid remote sensing method for assessing metabolite overproduction in titre improvement programmes. Global Drug Discovery: exploiting technologies to accelerate drug development, ed. Savage, L.M., publ. International Business Communications, Southborough, Mass, pp. 219-283.

Kell, D.B. & Todd, R.W. (1998) Dielectric estimation of microbial biomass using the Aber instruments biomass monitor. Trends Biotechnol. 16, 149-150.

Votyakova, T. V., Mukamolova, G. V., ShteinMargolina, V. A., Popov, V. I., Davey, H. M., Kell, D. B. & Kaprelyants, A. S. (1998) Research on the heterogeneity of a Micrococcus luteus culture during an extended stationary phase: Subpopulation separation and characterization. Microbiology (Russia) 67, 71-77.

Taylor, J., Goodacre, R., Wade, W.G., Rowland, J.J. & Kell, D.B. (1998) The deconvolution of pyrolysis mass spectra using genetic programming: application to the identification of some Eubacterium species. FEMS Microbiology Letters 160, 237- 246. Abstract.

Jones, A., Shaw, A.D., Salter, G.J., Bianchi, G. & Kell, D.B. (1998) The exploitation of chemometric methods in the analysis of spectroscopic data: application to olive oils. in Lipid Analysis of Oils and Fats (ed. R.J. Hamilton), publ. Chapman & Hall, pp 317-376.

Goodacre, R., Rooney, P.J. & Kell, D.B. (1998) Discrimination between susceptible and methicillin-resistant Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks. J. Antimicrobial Chemotherapy 41, 27-34. Abstract.

Winson, M. K., Todd, M., Rudd, B. A. M., Jones, A., Alsberg, B. K., Woodward, A. M., Goodacre, R., Rowland, J. J. & Kell, D. B. (1998) A DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking in Chemometrics) approach for the rapid analysis of microbial fermentation products: quantification of aristeromycin and neplanocin A in Streptomyces citricolor broths. New frontiers in screening for microbial biocatalysts (Kieslich, K., van der Beek, C.P., de Bont, J.A.M. & van den Tweel, W.J.J., eds), pp. 185-191. Elsevier, Amsterdam.

Kell, D.B., Winson, M.K., Goodacre, R., Woodward, A.M., Alsberg, B.K., Jones, A., Timmins, É and Rowland, J.J. (1998) DRASTIC (Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics). A novel, rapid, hyperspectral, FT-IR-based approach to screening for biocatalytic activity and metabolite overproduction. In New frontiers in screening for microbial biocatalysts (Kieslich, K., van der Beek, C.P., de Bont, J.A.M. & van den Tweel, W.J.J., eds), pp. 61-75. Elsevier, Amsterdam.






1997

Jones, A., Rowland, J.J., Woodward, A.M. & Kell, D.B. (1997) An instrument for the acquisition and analysis of the nonlinear dielectric spectra of biological samples. Trans. Inst. Meas. Control 19, 223-230.

Gilbert, R.J., Goodacre, R., Woodward, A.M. & Kell, D.B. (1997) Genetic programming: a novel method for the quantitative analysis of pyrolysis mass spectral data. Anal. Chem. 69, 4381-4389.

Goodacre, R., Timmins, É.M., Jones, A., Kell, D.B., Maddock, J., Heginbothom, M.L. and Magee, J.T. (1997) On mass spectrometer instrument standardization and interlaboratory calibration transfer using neural networks. Anal. Chim. Acta 348, 511-532.

Alsberg, B.K., Goodacre, R., Rowland, J.J. & Kell, D.B. (1997) Classification of pyrolysis mass spectra by fuzzy multivariate rule induction; comparison with regression, K- nearest neighbour, neural and decision-tree methods. Anal. Chim. Acta 348, 389-407.

Shaw, A.D., di Camillo, A., Vlahov, G., Jones, A., Bianchi, G., Rowland, J. & Kell, D.B. (1997) Discrimination of the variety and region of origin of extra virgin olive oils using 13C NMR and multivariate calibration with variable reduction. Anal. Chim. Acta 348, 357-374.

Winson, M.K., Goodacre, R., Timmins, É., Jones, A., Alsberg, B.K., Woodward, A.M., Rowland, J.J. & Kell, D.B. (1997) Diffuse Reflectance Absorbance Spectroscopy Taking In Chemometrics (DRASTIC). A hyperspectral FT-IR-based approach to rapid screening for metabolite overproduction. Anal. Chim. Acta 348, 273-282.

Broadhurst, D., Goodacre, R., Jones, A., Rowland, J.J. & Kell, D.B. (1997) Genetic algorithms as a method for variable selection in PLS regression, with applications to pyrolysis mass spectrometry. Anal. Chim. Acta 348, 71-86.

Tidswell, E.C., Salter, G.J., Kell, D.B. & Morris, J.G. (1997) Enantioselectivity of sulcatone reduction by some anaerobic bacteria. Enz. Micr. Technol. 21, 143-147.

Kell, D.B. (1997) Target practice - novel approaches to antimicrobial chemotherapy [meeting report]. Trends Biotechnol. 15, 334-336.

Davey, H.M. & Kell, D.B. (1997) Fluorescent brighteners: novel stains for the flow cytometric analysis of microorganisms. Cytometry 28, 311-315. Abstract.

Davey, C.L., Guan, Y., Kemp, R.B. & Kell, D.B. (1997) Real-time monitoring of the biomass content of animal cell cultures using dielectric spectroscopy. In Animal cell technology: basic and applied aspects, Vol 8, ed. K. Funatsu, Y. Shirai & T. Matsushita, pp. 61-65, publ. Kluwer, Dordrecht.

Alsberg, B.K., Woodward, A.M. & Kell, D.B. (1997) An introduction to wavelet transforms for chemometricians: a time-frequency approach. Chemometrics and Intelligent Laboratory Systems 37, 215-239.

Salter G.J., Lazzari M., Giansante L., Goodacre R., Jones, A., Surricchio G., Kell D.B. and Bianchi G. (1997) Determination of the geographical origin of Italian extra virgin olive oil using pyrolysis mass spectrometry and artificial neural networks. J. Anal. Appl. Pyrol. 40/41, 159-170.

Goodacre, R., Hammond, D. & Kell, D.B. (1997) Quantitative analysis of the adulteration of orange juice with sucrose using pyrolysis mass spectrometry and chemometrics. J. Anal. Appl. Pyrol. 40/41, 135-158.

Alsberg, B.K., Woodward, A.M., Winson, M.K., Rowland, J.J. and Kell, D.B. (1997) Wavelet denoising of infrared spectra. Analyst 122, 645-652.

Alsberg, B.K., Winson, M.K. & Kell, D.B. (1997) Improving interpretation of multivariate and rule induction models by using a spectral peak parameter representation. Chemometrics and Intelligent Laboratory Systems, 36, 95-109.

Winson, M.K. & Kell, D.B. (1997) If you've got it, flaunt it - rapid screening for microbial biocatalysts [meeting report] Trends Biotechnol. 15, 120-122.

Mendes, P. & Kell, D.B. (1997) Making cells work - metabolic engineering for everyone. [meeting report] Trends Biotechnol. 15, 6-7.






1996

Goodacre, R., Rischert, D.J., Evans, P.M. & Kell, D.B. (1996) Rapid authentication of animal cell lines using pyrolysis mass spectrometry and auto-associative artificial neural networks. Cytotechnology 21, 231-241.

Davey, H.M. & Kell, D.B. (1996) Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses. Microbiol. Rev. 60, 641-696. Abstract.

Westerhoff, H.V. & Kell, D.B. (1996) What BioTechnologists knew all along...? J. Theoret. Biol. 182, 411-420. Abstract.

Woodward, A.M., Jones, A., Zhang, X.-Z., Rowland, J. & Kell, D.B. (1996) Rapid and non-invasive quantification of metabolic substrates in biological cell suspensions using nonlinear dielectric spectroscopy with multivariate calibration and artificial neural networks. Principles and applications. Bioelectrochem. Bioenerg. 40, 99-132.

Goodacre, R., Neal, M.J. & Kell, D.B. (1996) Quantitative analysis of multivariate data using artificial neural networks: a tutorial review and applications to the deconvolution of pyrolysis mass spectra. Zentralblatt. für Bakteriologie 284, 516-539. Abstract.

Kell, D.B., Goodacre, R. & Neal, M.J. (1996) Rapid analysis of multiple determinands using pyrolysis mass spectrometry and supervised learning with artificial neural networks. In (Berg, D.A., ed.) Proc. 1994 ERDEC Scientific Conference on chemical and biological defense research, pp 53-59. ERDEC-SP-036, Aberdeen Proving Ground.

Mendes, P. & Kell, D.B. (1996) Biothermokinetics, metabolic control analysis, metabolic engineering and the World Wide Web: rapid dissemination over the Internet. In Westerhoff H.V., Snoep J.L., Sluse F.E., Wijker J.E. and Kholodenko B.N. (eds.) BioThermoKinetics of the Living Cell, pp. 254-257, BioThermoKinetics Press, Amsterdam.

Mendes, P. & Kell, D.B. (1996) Computer simulation of biochemical kinetics. In Westerhoff H.V., Snoep J.L., Sluse F.E., Wijker J.E. and Kholodenko B.N. (eds.) BioThermoKinetics of the Living Cell, pp. 245-251, BioThermoKinetics Press, Amsterdam.

Goodacre, R., Pygall, J. & Kell, D.B. (1996) Plant seed classification using pyrolysis mass spectrometry with unsupervised learning; the application of auto-associative and Kohonen artificial neural networks. Chemometr. Intell. Lab. Syst., 34, 69-83.

Winson, M.K. & Kell, D.B. (1996) Going places: forced and natural molecular evolution (Meeting report). Trends Biotechnol. 14, 323-325.

Goodacre, R., Timmins, É.M., Rooney, P.J., Rowland, J.J. & Kell, D.B. (1996) Rapid identification of Streptococcus species using diffuse reflectance-absorbance Fourier transform infrared spectroscopy and artificial neural networks. FEMS Microbiol. Lett. 140, 233-239. Abstract.

Davey, H.M., Davey, C.L., Woodward, A.M., Edmonds, A.N., Lee, A.W. & Kell, D.B. (1996) Oscillatory, stochastic and chaotic growth rate fluctuations in permittistatically- controlled yeast cultures. Biosystems 39, 43-61. Abstract.

Kell, D.B. (1996) Membrane tension (letter). Trends Cell Biol. .6, 171.

Kaprelyants, A.S. & Kell, D.B. (1996) Do bacteria need to communicate with each other for growth? Trends Microbiol. 4, 237-242. Abstract.

Kaprelyants, A.S., Mukamolova, G.V., Davey, H.M. & Kell, D.B. (1996) Quantitative analysis of the physiological heterogeneity within starved cultures of Micrococcus luteus using flow cytometry and cell sorting. Appl. Env. Microbiol. 62, 1311-1316.

Nicholson, D.J., Kell, D.B. & Davey, C.L. (1996) Deconvolution of the dielectric spectra of microbial cell suspensions using multivariate calibration and artificial neural networks. Bioelectrochem. Bioenerg. 39, 185-193.

Goodacre, R. & Kell, D.B. (1996) Neural network analyses of pyrolysis mass spectral data: applications to the assessment of food adulteration, monitoring fermentor broths, and the correction of mass spectral drift. Proceedings of MolMass 96 - 2nd International Conference on Molecular Mass Characterization of Synthetic and Natural Polymers, 1-4 April, 1996. 7 pp

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1996) Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel. Biochim. Biophys. Acta 1289, 175-186. Abstract.

Mendes, P. & Kell, D.B. (1996) On the analysis of the inverse problem of metabolic pathways using artificial neural networks. Biosystems 38, 15-28. Abstract.

Goodacre, R. & Kell, D.B. (1996) Pyrolysis mass spectrometry and its applications in biotechnology. Curr. Opinion Biotechnol. 7, 20-28. Abstract.

Goodacre, R. & Kell, D.B. (1996) Correction of mass spectral drift using artificial neural networks. Anal. Chem. 68, 271-280. Abstract.






1995

Kell, D.B., Davey, H.M., Mukamolova, G.V., Votyakova, T.V. & Kaprelyants, A.S. (1995) A summary of recent work on dormancy in non-sporulating bacteria: significance for marine microbiology and biotechnology. J. Marine Biotechnol. 3, 24-25.

Davey, C.L. & Kell, D.B. (1995) The low-frequency dielectric properties of biological cells. In (D. Walz, H. Berg & G. Milazzo, eds) Bioelectrochemistry of cells and tissues, pp. 159-207, Birkhäuser, Zürich.

Kell, D.B. & Sonnleitner, B. (1995) GMP - Good Modelling Practice: an essential component of good manufacturing practice. Trends Biotechnol., 13, 481-492.

Goodacre, R., Trew, S., Wrigley-Jones, C., Saunders, G., Neal, M.J., Porter, N. & Kell, D.B. (1995) Rapid and quantitative analysis of metabolites in fermentor broths using pyrolysis mass spectrometry with supervised learning: application to the screening of Penicillium chryosgenum fermentations for the overproduction of penicillins. Anal. Chim. Acta 313, 25-43.

Salter, G.J. and Kell, D.B. (1995) Solvent selection for whole cell biotransformations in organic media. CRC Crit Rev. Biotechnol. 15, 139-177. Abstract.

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1995) A series of cases in which metabolic channeling can decrease the pool size at constant net flux in a simple dynamic channel. Biochem. Soc. Trans. 23, S 287

Woodward, A.M. & Kell, D.B. (1995) On harmonic generation in nonlinear biological systems. Biosensors Bioelectronics 10, 639-641.

Goodacre, R., Biamchi, G. & Kell, D.B. (1995) Food adulteration exposed by neural networks. Analysis Europa, June issue, pp. 35-37.

Mukamolova G.V., Yanopolskaya N.D., Votyakova T.V., Popov V.I., Kaprelyants A.S. & Kell D.B. (1995) Biochemical changes accompanying the long-term starvation of Micrococcus luteus cells in spent growth medium. Arch. Microbiol. 163, 373-379.

Mendes, P., Kell, D.B. & Welch, G.R. (1995) Metabolic channeling in organized enzyme systems: experiments and models. In: Enzymology in vivo (Adv. Mol. Cell. Biol. 11, 1-19) (ed. K. Brindle), JAI Press, London. Manuscript in pdf .

Mukamolova, G.V., Kaprelyants, A.S. & Kell, D.B. (1995) Secretion of an antibacterial factor during resuscitation of dormant cells in Micrococcus luteus cultures held in an extended stationary phase. Antonie van Leeuwenhoek, 67, 289-295. Abstract.

Markx, G.H. & Kell, D.B. (1995) The use of dielectric permittivity for the control of the biomass level during biotransformations of toxic substrates in continuous culture. Biotechnology Progress, 11, 64-70. Abstract.

Kell, D.B., Kaprelyants, A.S. & Grafen, A. (1995) On pheromones, social behaviour and the functions of secondary metabolism in bacteria. Trends Ecol. Evolution 10, 126- 129.






1994

Davey, H.M. and Kell, D.B. (1994) Rapid flow cytometric detection and identification of microbial particles. In (Berg, D.A., ed.) Proc. 1994 ERDEC Scientific Conference on chemical and biological defense research, pp 593-599. ERDEC-SP-036, Aberdeen Proving Ground.

Tatebe, W., Woodward, A.M. & Kell, D.B. (1994) Nonlinear dielectric properties and their relationship to the physiological state (resting or active) of Saccharomyces cerevisiae. Mem. Fac. Eng. Osaka City Univ. 35, 53-57.

Goodacre, R., Trew, S., Wrigley-Jones, C., Neal, M.J., Maddock, J., Ottley, T.W., Porter, N. & Kell, D.B. (1994) Rapid screening for metabolite overproduction in fermentor broths, using pyrolysis mass spectrometry with multivariate calibration and artificial neural networks. Biotechnol. Bioeng. 44, 1205-1216.

Kell, D.B., Goodacre, R. & Neal, M.J. (1994) The dogs that did not bark. Trends Biotechnol. 12, 494-495 (refereed letter).

Mendes, P. & Kell, D.B. (1994) Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks. in What is controlling life? 50 years after Schrödinger's What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 302-304. Innsbruck University Press, Innsbruck.

Kell, D.B., Davey, H.M., Mukamolova, G.V., Votyakova, T.V. & Kaprelyants, A.S. (1994) Life, death, dormancy and social resuscitation in non-sporulating bacteria: relationships with the energetic status of individual cells. in What is controlling life? 50 years after Schrödinger's What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 252-254. Innsbruck University Press, Innsbruck.

Mendes, P, Kell, D.B. & Westerhoff, H.V. (1994) How to vary the proportion of dynamic channelling flux at constant total flux (and decrease the intermediate pool size...). in What is controlling life? 50 years after Schrödinger's What is Life? (E. Gnaiger, F.N. Gellerich & M. Wyss, eds) Modern Trends in Biothermokinetics Vol 3, 202-204. Innsbruck University Press, Innsbruck.

Beving, H., Eriksson, L.E.G., Davey, C.L. & Kell, D.B. (1994) Dielectric properties of human erythrocytes and blood at radio frequencies (0.2 - 10 MHz); dependence on cell volume fraction and medium composition. Eur. Biophys. J. 23, 207-215. Abstract.

Votyakova, T.V., Kaprelyants, A.S. & Kell, D.B. (1994) Influence of viable cells on the resuscitation of dormant cells in Micrococcus luteus cultures held in extended stationary phase. The population effect. Appl. Env. Microbiol. 60, 3284-3291.

Kell, D.B. & Woodward, A.M. (1994) The nonlinear dielectric properties of biological systems: a set of methods for assessing the behaviour of enzymes in situ. In (H.V. Westerhoff, ed.) Biothermokinetics. Intercept Press, London, pp 431-434.

Neal, M.J., Goodacre, R. & Kell, D.B. (1994) On the analysis of pyrolysis mass spectra using artificial neural networks. Individual input scaling leads to rapid learning. Proceedings of the World Congress on Neural Networks 1994, San Diego, I-318 - I-323.

Goodacre, R., Karim, A., Kaderbhai, M. & Kell, D.B. (1994) Rapid and quantitative analysis of recombinant protein expression using pyrolysis mass spectrometry and artificial neural networks: application to mammalian cytochrome b5 in Escherichia coli. J. Biotechnol., 34, 185-193. Abstract.

Goodacre, R., Neal, M.J. & Kell, D.B. (1994) Rapid and quantitative deconvolution of the pyrolysis mass spectra of complex binary and tertiary mixtures using multivariate calibration and artificial neural networks. Anal. Chem., 66, 1070-1085.

Kell, D.B. (1994) Between the bud and the rose [book review]. Trends Biochem. Sci. 19, 184.

Kaprelyants, A.S., Mukamolova, G.V. & Kell, D.B. (1994) Estimation of dormant Micrococcus luteus cells by penicillin lysis and by resuscitation in cell-free spent culture medium at high dilution. FEMS Microbiol. Lett., 115, 347-352.






1993

Goodacre, R., Neal, M.J., Kell, D.B., Greenham, L.W., Noble, W.C. & Harvey, R.G. (1993) Rapid identification using pyrolysis mass spectrometry and artificial neural networks of Propionibacterium acnes isolated from dogs. J. Appl. Bacteriol., 76, 124-134. Abstract.

Mendes, P. & Kell, D.B. (1993) Control analysis of metabolic channelling. Modern Trends in Biothermokinetics, eds S. Schuster, M. Rigoulet, R. Ouhabi & J.-P. Mazat, Plenum Press, New York and London, 211-216.

Kell, D.B., Davey, C.L., Goodacre, R. & Sauro, H.M. (1993) When going backwards means progress: on the solution of biochemical inverse problems using artificial neural networks. Modern Trends in Biothermokinetics, eds S. Schuster, M. Rigoulet, R. Ouhabi & J.-P. Mazat, Plenum Press, New York and London, 109-114.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid assessment using pyrolysis mass spectrometry and artificial neural networks of the adulteration of virgin olive oils by other seed oils. J. Sci. Food Agric. 63, 297-307.

Davey, H.M., Davey, C.L. & Kell, D.B. (1993) SKATGRAF: a stand-alone program for the calibration and plotting of flow cytometric data. Binary 5, 165-170.

Mendes, P. & Kell, D.B. (1993) On the role of enzyme kinetic parameters in determining the effectiveness with which channelling can decrease the size of a metabolite pool. Acta Biotheoretica 41, 63-73. Abstract.

Kaprelyants, A.S. & Kell, D.B. (1993) Dormancy in stationary-phase cultures of Micrococcus luteus: flow cytometric analysis of starvation and resuscitation. Appl. Env. Microbiol. 59, 3187-3196.

Goodacre, R. Edmonds, A.N. & Kell, D.B. (1993) Quantitative analysis of the pyrolysis mass spectra of complex mixtures using artificial neural networks: application to amino acids in glycogen. J. Anal. Appl. Pyrol. 26, 93-114.

Davey, C.L., Markx, G.H. & Kell, D.B. (1993) On the dielectric method of monitoring cellular viability. Pure Appl. Chem. 65, 1921-1926.

Davey, C.L., Davey, H.M., Kell, D.B. & Todd, R.W. (1993) An introduction to the dielectric estimation of cellular biomass in real time, with special emphasis on measurements at high volume fractions. Anal. Chim. Acta 279, 155-161.

Goodacre, R. & Kell, D.B. (1993) Rapid analysis of bioprocesses using pyrolysis mass spectrometry and neural networks: application to indole production. Anal. Chim. Acta 279, 17-26.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Olive oil quality control by using pyrolysis mass spectrometry and artificial neural networks. Olivæ 47, 36-38.

Goodacre, R., Kell, D.B. & Bianchi, G. (1993) Rapid assessment of food adulteration using pyrolysis mass spectrometry and neural networks: application to extra virgin olive oils. Central Office of Information Newsletter.

Kaprelyants, A.S., Gottschal, J.C. & Kell, D.B. (1993) Dormancy in nonsporulating bacteria. FEMS Microbiol. Rev. 104, 271-286.

Kell, D.B., Westerhoff, H.V., Fell, D., Thomas, S. & Mendes, P. (1993) Demonstration programs illustrating the modelling of metabolic systems [meeting report], Binary 5, 47-49.

Davey, H.M., Kaprelyants, A.S. & Kell, D.B. (1993) Flow cytometric analysis, using rhodamine 123, of Micrococcus luteus at low growth rate in chemostat culture. In Flow cytometry in microbiology, ed. D. Lloyd, Springer-Verlag, Heidelberg, pp. 83- 93.

Davey, H.M., Davey, C.L. & Kell, D.B. (1993) On the determination of the size of microbial cells using flow cytometry. In Flow cytometry in microbiology, ed. D. Lloyd, Springer-Verlag, Heidelberg, pp. 49-65.

Kaprelyants, A.S. & Kell, D.B. (1993) The use of 5-cyano-2,3-ditolyl tetrazolium chloride and flow cytometry for the visualisation of respiratory activity in individual cells of Micrococcus luteus. J. Microbiol. Methods. 17, 115-122.






1992

Sauro, H.M. & Kell, D.B. (1992) Evaluation of steady-state kinetic parameters of metabolic pathways using neural networks. Binary, 4, 189-190.

McShea, A., Woodward, A.M. & Kell, D.B. (1992) Non-linear dielectric properties of Rhodobacter capsulatus. Bioelectrochem. Bioenerg. 29, 205-214.

Salter, G.J. & Kell, D.B. (1992) Rapid determination, using dielectric spectroscopy, of the toxicity of organic solvents to intact cells. In Fundamentals of biocatalysis in non- conventional media, ed. J. Tramper, M.H. Vermüe, H.H. Beeftink & U. von Stockar, pp. 291-297. Elsevier, Amsterdam.

Goodacre, R., Kell, D.B. & Bianchi, G. (1992) Neural networks and olive oil. Nature 359, 594.

Kell, D.B. & Davey, C.L. (1992) On fitting dielectric spectra using artificial neural networks. Bioelectrochem. Bioenerg. 28, 425-434.

Davey, C.L., Davey, H.M. & Kell, D.B. (1992) On the dielectric properties of cell suspensions at high volume fractions. Bioelectrochem. Bioenerg. 28, 319-340.

Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B. (1992) Physiological studies on the quinoa tempe fermentation, using on-line measurements of fungal biomass production. J. Sci. Food Agric., 59, 227-235.

Salter, G.J. & Kell, D.B. (1992) New materials and technology for cell immobilisation. Current Opinion in Biotechnology, 3, 115-118. Abstract.

Kell, D.B. (1992) Biophysics for the next century, in G. Arcidiacono, U. Bartocci & M. Mamone Capria (eds.) What physics for the next century?, p. 17. Società Editrice Andromeda, Bologna.

Kell, D.B. (1992) The protonmotive force as an intermediate in electron transport-linked phosphorylation: problems and prospects. Curr. Top. Cell. Reg., 33, 279-289.

Kell, D.B. (1992) "Scanning Tunnelling Microscopy" in biology; are the current carriers tunnelling electrons or hydrated protons? Bioelectrochem. Bioenerg., 27, 235-237.

Kaprelyants, A.S. & Kell, D.B. (1992) Rapid assessment of bacterial viability and vitality using rhodamine 123 and flow cytometry. J. Appl. Bacteriol., 72, 410-422.

Kell, D.B., Davey, C.L. & Todd, R.W. (1992) Real-time measurement of cellular biomass using dielectric spectroscopy. In. Biotechnology International, 2nd Edition (R.N. Greenshields, ed), pp. 294-297, publ. Grosvenor Press, London.

Kell, D.B. & Woodward, A.M. (1992) Analysis of biological material by a nonlinear dielectric spectrum. UK Patent 2 247 530 (granted 4.5.94).

Mendes, P., Kell, D.B. & Westerhoff, H.V. (1992) Channelling can decrease pool size. Eur. J. Biochem., 204, 257-266. Abstract.






1991

Westerhoff, H.V., van Heeswijk,W., Kahn, D. & Kell, D.B. (1991) Quantitative approaches to the analysis of the control and regulation of microbial metabolism. Antonie. van Leeuwenhoek 60, 193-207. Abstract.

Kell, D.B., Ryder, H.M., Kaprelyants, A.S. & Westerhoff, H.V. (1991) Quantifying heterogeneity: flow cytometry of bacterial cultures. Antonie van Leeuwenhoek 60, 145-158. Abstract.

Woodward, A.M. & Kell, D.B. (1991) On the relationship between the nonlinear dielectric properties and respiratory activity of the obligately aerobic bacterium Micrococcus luteus. Bioelectrochem. Bioenerg. 26, 423-439.

Woodward, A.M. & Kell, D.B. (1991) Confirmation using mutant strains that the membrane-bound H+-ATPase is the major source of nonlinear dielectricity in Saccharomyces cerevisiae. FEMS Microbiol. Lett., 84, 91-96. Abstract.

Kell, D.B. & Woodward, A.M. (1991) Nonfaradaic electrochemical sensors: principles and practice. Anal. Proc., 28, 378-379.

Markx, G.H., Davey, C.L., Kell, D.B. & Morris, P. (1991) The dielectric permittivity at radio frequencies and the Bruggeman probe: novel techniques for the on-line determination of biomass concentrations in plant cell cultures. J. Biotechnol. 20, 279-290.

Kell, D.B. (1991) On the physiological significance of metabolic channelling; if, how and when, but not why. J. Theoret. Biol., 152, 49-51.

Kell, D.B. & Welch, G.R. (1991) No turning back: reductionism and biological complexity. Times Higher Educational Supplement, 9th August, p. 15. pdf of manuscript.

Woodward, A.M. & Kell, D.B. (1991) Dual-frequency excitation: a novel method for probing the nonlinear dielectric properties of biological systems, and its application to suspensions of S. cerevisiae. Bioelectrochem. Bioenerg., 25, 395-413.

Kell, D.B. (1991) Bioinstrumentation: research, development and applications [book review]. SGM Quarterly 18, 67.

Salter, G.J. & Kell, D.B. (1991) New materials and technology for cell immobilisation. Current Opinion in Biotechnology, 2, 385-389. Abstract.

Kell, D.B. (1991) Paying for the privilege. [Technology Transfer in Japan and the UK] Times Higher Educational Supplement, June 26, p. VI.

Markx, G.H., Davey, C.L. & Kell, D.B. (1991) To what extent is the value of the Cole-Cole a of the β-dielectric dispersion of cell suspensions accountable in terms of the cell size distribution? Bioelectrochem. Bioenerg. 25, 195-211.

Peñaloza, W., Davey, C.L., Hedger, J.N. & Kell, D.B. (1991) Stimulation by potassium of the growth of Rhizopus oligosporus during liquid- and solid-substrate fermentations. World J. Microbiol. Biotechnol, 7, 260-268.

Davey, C.L., Peñaloza, W., Kell, D.B. & Hedger, J.N. (1991) Real- time monitoring of the accretion of Rhizopus oligosporus biomass during the solid-substrate tempe fermentation. World J. Microbiol. Biotechnol, 7, 248-259.

Kell, D.B. (1991) Lacuna seeker [letter]. Nature 350, 268. Kell, D.B. (1991) Biosensor Technology: Fundamentals and Applications. : R.P. Buck, E.F. Bowden, M. Umaña and W.E. Hatfield (Editors). Marcel Dekker, New York, 1990[BOOK REVIEW]

Markx, G.H., Davey, C.L. & Kell, D.B. (1991) The permittistat: a novel type of turbidostat. J. Gen. Microbiol., 137, 735-743.







1990

Kell, D.B. (1990) Solutions, but no answers [book review]. Trends Biochem. Sci. 16, 164.

Kell, D.B. (1990) Determination of biomass. U.S. Patent # 4, 965, 206 of October 23rd.

Woodward, A.M. & Kell, D.B. (1990) On the nonlinear dielectric properties of biological systems. Saccharomyces cerevisiae. Bioelectrochem. Bioenerg., 24, 83- 100.

Markx, G.H. & Kell D.B. (1990) Dielectric spectroscopy as a tool for the measurement of the formation of biofilms and of their removal by electrolytic cleaning pulses and biocides. Biofouling, 2, 211-227.

Davey, C.L., Kell, D.B. & Dixon, N.M. (1990) SKATFIT: A program for determining the mode of growth of individual microbial cells from flow cytometric data. Binary, 2, 127-132.

Davey, C.L., Dixon, N.M. & Kell, D.B. (1990) FLOWTOVP: a spreadsheet method for linearising flow cytometric light-scattering data used in cell sizing. Binary, 2, 119-125.

James, E.W., Dixon, N.M., Denholm, A.M., Kell, D.B. & Morris, J.G. (1990) Electromicrobial and related approaches to anaerobic biotransformations. In: Opportunities in Biotransformations (L.G. Copping, R.E. Martin, J.A. Pickett, C. Bucke & A.W. Bunch, eds.), pp. 195-202. Elsevier Applied Science, London.

Kell, D.B. & Davey, C.L. (1990) Conductimetric and Impedimetric Devices. In: Biosensors: a practical approach (A.E.G. Cass, ed.), IRL Press, Oxford, pp. 125- 154.

Ferris, L.E., Davey, C.L. & Kell, D.B. (1990) Evidence from its temperature- dependence that the β-dielectric dispersion of cell suspensions is not due solely to the charging of a static membrane capacitance. Eur. Biophys. J., 18, 267-276.

Davey, C.L., Markx, G.H. & Kell, D.B. (1990) Substitution and spreadsheet methods for analysing dielectric spectra of biological systems. Eur. Biophys. J., 18, 255-265.

Kell, D.B. & Westerhoff, H.V. (1990) Metabolic control analysis: theory and practice. In: Mixed and multiple substrates and feedstocks, ed. G. Hamer, T. Egli & M. Snozzi, pp.107-119, Hartung-Gorre, Konstanz.

Kell, D.B., Markx, G.H., Davey, C.L. & Todd, R.W. (1990) Real-time monitoring of cellular biomass: methods and applications. Trends Anal. Chem., 9, 190-194.

Salter, G.J., Kell, D.B., Ash, L.A., Adams, J.M., Brown, A.J. & James, R. (1990) Hydrodynamic deposition: a novel method of cell immobilisation. Enz. Micr. Technol., 12, 419-430. Abstract.

Markx, G.H., Davey, C.L., Todd, R.W. & Kell, D.B. (1990) The real time measurement of biomass accretion using dielectric spectroscopy. In: Practical advances in fermentation technology, Institution of Chemical Engineers, North Western Branch, Symposium Papers No 3, pp. 5.1-5.9.

Davey, C.L. & Kell, D.B. (1990) The dielectric properties of cells and tissues: what can they tell us about cellular physiology and the mechanisms of field/cell interactions? In: Emerging Electromagnetic Medicine (ed. M.E. O'Connor, R.H.C. Bentall & J.C. Monahan). Springer-Verlag, New York., pp. 19-43.

Kell, D.B. & Westerhoff, H.V. (1990) Control analysis of organised multienzyme systems. In: Structural and organizational aspects of metabolic regulation, UCLA Symposia on Molecular and Cellular Biology, New Series, Vol 134 (P. Srere, M.E. Jones & C. Mathews, eds), pp. 273-289. Alan R. Liss, New York.






1989

Dixon, N.M. & Kell, D.B. (1989) The control and measurement of "CO2" during fermentations. J. Microbiol. Methods, 10, 155- 176. Walter, R.P., Kell, D.B., Morris, J.G., James, R. & Adams, J.M. (1989) Catalytic activity of Candida cylindracea lipase immobilised on ceramic supports. Biotechnol. Tech., 3, 345-348.

Stoicheva, N., Davey, C.L., Markx, G.H. & Kell, D.B. (1989) Dielectric spectroscopy: a rapid method for the determination of solvent biocompatibility during biotransformations. Biocatalysis 2, 245-255.

Dixon, N.M. & Kell, D.B. (1989) The inhibition by CO2 of the growth and metabolism of microorganisms. J. Appl. Bacteriol., 67, 109-136.

Dixon, N.M., James, E.W., Lovitt, R.W. & Kell, D.B. (1989) Electromicrobial transformations using the pyruvate synthase system of Clostridium sporogenes. Bioelectrochem. Bioenerg. 21, 245-259.

Kell, D.B. (1989) Biosensors [book review] Bioelectrochem. Bioenerg. 21, 110-111.

Kell, D.B. (1989) Window boxes? [letter] Nature 338, 612.

Kell, D.B. & Todd, R.W. (1989) Determination of Biomass. US Patent # 4,810,650 of March 7th.

Davey, C.L. & Kell, D.B. (1989) Low-frequency dielectric properties of cell suspensions. In: Electric Field Phenomena in Biological Systems (R. Paris, ed.) Institute of Physics Short Meetings 21, 51-63. IOP Publishing, Bristol.

Kell, D.B., van Dam, K. & Westerhoff, H.V. (1989) Control analysis of microbial growth and productivity. Symp. Soc. Gen. Microbiol. 44, 61-93.







1988

Westerhoff, H.V., Kell, D.B., Kamp, F. & van Dam, K. (1988) The membranes involved in proton-mediated free-energy transduction: thermodynamic implications of their physical structure. In: Microcompartmentation (D.P. Jones, ed.) CRC Press, Boca Raton, pp. 115-154.

Westerhoff, H.V., Astumian, R.D. & Kell, D.B. (1988) Mechanisms for the interaction between nonstationary electric fields and biological systems. II. Nonlinear dielectric theory and free-energy transduction. Ferroelectrics 86, 79-101.

Kell, D.B., Astumian, R.D. & Westerhoff, H.V. (1988) Mechanisms for the interaction between nonstationary electric fields and biological systems. I. Linear dielectric theory and its limitations. Ferroelectrics 86, 59-78.

Davey, C.L., Kemp, R.B., Meredith, R.W.J. & Kell, D.B. (1988) On the audio- and radio-frequency dielectric behaviour of anchorage-independent, mouse L929-derived LS fibroblasts. Bioelectrochem. Bioenerg. 20, 83-98.

James, E.W., Kell, D.B., Lovitt, R.W. & Morris, J.G. (1988) Electrosynthesis and electroanalysis using Clostridium sporogenes. Bioelectrochem. Bioenerg. 20, 21- 32.

Kell, D.B. (1988) Biosensors: fundamentals and applications [book review]. Bioelectrochem. Bioenerg. 19, 589.

Dixon, N.M., Lovitt, R.W., Morris, J.G. & Kell, D.B. (1988) Growth energetics of Clostridium sporogenes NCIB 8053: modulation by CO2. J. Appl. Bacteriol. 65, 119-134.

Kell, D.B. (1988) Protonmotive energy-transducing systems: some physical principles and experimental approaches. In: Bacterial Energy Transduction (C.J. Anthony, ed.), pp. 429-490. Academic Press, London.

Westerhoff, H.V., Kell, D.B. & Astumian, R.D. (1988) The dynamics of electrostatic interactions between membrane proteins. J. Electrostatics 21, 257-298.

Kell, D.B. (1988) Electronic measurement of cellular biomass. Trends in Biotechnol. 6, 268-269.

Adams, J.M., Ash, L.A., Brown, A.J., James, R., Kell, D.B., Salter G.J. & Walter, R.P. (1988) A range of ceramic biosupports. Int. Biotechnol. Lab. 6 (3), 22-27.

Kell, D.B. (1988) A theoretical treatise [Book Review]. Trends Biochem. Sci. 13, 406.

Pugh, S.Y.R., James, E.W., Kell, D.B. & Morris, J.G. (1988) Biotransformations Club Report: Cofactor recycling during biotransformations, 35pp. Laboratory of the Government Chemist.

Kell, D.B. (1988) Coherent properties of energy-coupling membrane systems. In: Biological Coherence and Response to External Stimuli (H. Fröhlich, ed.). Springer, Heidelberg, pp. 233-241.

Westerhoff, H.V. & Kell, D.B. (1988) A control theoretical analysis of inhibitor titrations of metabolic channelling. Comments Mol. Cell. Biophys. 5, 57-107.

Kell, D.B. (1988) Dielectric Spectroscopy of Biological Systems. In: ISI Atlas of Science: Biochemistry. Vol 1, 25-29. Institute for Scientific Information, Philadelphia.






1987

Kell, D.B. (1987) Energetics of Microbial Growth [book review]. Q. Rev. Biol. 62, 443-444.

Lovitt, R.W., James, E.W., Kell, D.B. & Morris, J.G. (1987) Bioelectrochemical transformations catalysed by Clostridium sporogenes, In: Bioreactors and Biotransformations (G.W. Moody & P.B. Baker, eds) pp.263-276. Elsevier Applied Science Publishers, London.

Dixon, N.M., Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) Effects of pCO2 on the growth and metabolism of Clostridium sporogenes NCIB 8053 in defined media. J. Appl. Bacteriol. 63, 171-182.

Kell, D.B. (1987) Non-thermally excited modes and free energy transduction in proteins and biological membranes. In: Energy Transfer Dynamics (T.W. Barrett & H.A. Pohl, eds), pp. 237-246. Springer, Heidelberg.

Kell, D.B. (1987) Forces, fluxes and the control of microbial growth and metabolism. The twelfth Fleming lecture. J. Gen. Microbiol. 133, 1651-1665.

Westerhoff, H.V. & Kell, D.B. (1987) Matrix method for determining the steps most rate-limiting to metabolic fluxes in biotechnological processes. Biotechnol. Bioeng. 30, 101- 107.
Selected as a Vintage Paper in Nielsen, J. (2009) Vintage Paper: Quantification of Flux Control in Metabolic Pathways. Biotechnol. Bioeng. 104, No.1, 3-9.

Pethig, R. & Kell, D.B. (1987) The passive electrical properties of biological systems: their role in physiology, biophysics and biotechnology. Phys. Med. Biol. 32, 933-970.

Kell, D.B., Samworth, C.M., Todd, R.W., Bungard, S.J. & Morris, J.G. (1987) Real-time estimation of microbial biomass during fermentations, using a dielectric probe. Studia Biophys. 119, 153-156.

Kell, D.B. (1987) The principles and potential of electrical admittance spectroscopy: an introduction. In: Biosensors; fundamentals and applications (A.P.F.Turner, I.Karube & G.S. Wilson, eds.), pp. 427-468. Oxford University Press.

Kell, D.B. (1987) Bioelectrochemical phenomena: their role and exploitation in science and technology. University of Wales Rev. Sci. Technol. 1, 64-71.

Walter, R.P., Kell, D.B. & Morris, J.G. (1987) The roles of osmotic stress and water activity in the inhibition of the growth, glycolysis and glucose phosphotransferase system of Clostridium pasteurianum. J. Gen. Microbiol. 133, 259-266. Abstract.

Lovitt, R.W., Morris, J.G. & Kell, D.B. (1987) The growth and nutrition of Clostridium sporogenes NCIB 8053 in defined media. J. Appl. Bacteriol. 62, 71- 80. Abstract.

Lovitt, R.W., Kell, D.B. & Morris, J.G. (1987) The physiology of Clostridium sporogenes NCIB 8053 growing in defined media. J. Appl. Bacteriol. 62, 81-92. Abstract.

Harris, C.M., Todd, R.W., Bungard, S.J., Lovitt, R.W., Morris, J.G. & Kell, D.B. (1987) The dielectric permittivity of microbial suspensions at radio frequencies: a novel method for the real-time estimation of microbial biomass. Enz. Micr. Technol. 9, 181-186.






1986

Symons, M.R., Korenstein, R., Harris, C.M. & Kell, D.B. (1986) Dielectric properties of energy coupling membranes: chloroplast thylakoids. Bioelectrochem. Bioenerg. 16, 45-54.

Kell, D.B. & Walter, R.P. (1986) Organisation and control of energy metabolism in anaerobic microorganisms. In: The Organisation of Cell Metabolism (G.R. Welch & J.S. Clegg, eds.), pp. 215-231. Plenum Press, New York.

Kell, D.B. (1986) On the lateral mobility of proteins in prokaryotic membranes. Biochem. Soc. Trans. 14, 825-826.

Harris, J., Mulder, R., Kell, D.B., Walter, R.P. & Morris, J.G. (1986) Solvent production by Clostridium pasteurianum in media of high sugar content. Biotechnol. Lett. 8, 889-892.

Lovitt, R.W., Kell, D.B. & Morris, J.G. (1986) Proline reduction by Clostridium sporogenes is coupled to vectorial proton ejection. FEMS Microbiol. Lett. 36, 269- 273.

Kell, D.B. (1986) Uncoupler titrations in co-reconstituted systems do not discriminate between localized and delocalized mechanisms of photophosphorylation. Biochem. J. 236, 931-932.

Kell, D.B. & Westerhoff, H.V. (1986) Towards a rational approach to the optimization of flux in microbial biotransformations. Trends in Biotechnol. 4, 137-142.

Kell, D.B. & Westerhoff, H.V. (1986) Metabolic control theory: its role in microbiology and biotechnology. FEMS Microbiol. Rev. 39, 305-320.

Kell, D.B. (1986) Foreword. In: Modern Bioelectrochemistry (F. Gutmann & H. Keyzer, eds.) pp. x-xi. Plenum Press, New York.

Harris, C.M. & Kell, D.B. (1986) Dielectric Spectroscopy of protein translational diffusion in prokaryotic membranes. Bioelectrochem. Bioenerg. 15, 183-184.

Welch, G.R. & Kell, D.B. (1986) Not just catalysts; the bioenergetics of molecular machines. In: The Fluctuating Enzyme (G.R. Welch, ed.), pp. 451-492. Wiley, New York.

Kell, D.B. (1986) Localized protonic coupling: overview and critical evaluation of techniques. Meth. Enzymol. 127, 538-557.

Kell, D.B. & Burns, A. (1986) A nomograph for calculating the optimal frequency for dielectrophoresis and the characteristic frequency of the β-dispersion of cell membrane vesicles. J. Bioelectricity, 5, 139-144.

Lovitt, R.W., Walter, R.P., Morris, J.G. & Kell, D.B. (1986) Conductimetric assessment of the biomass content in suspensions of immobilised (gel-entrapped) microorganisms. Appl. Microbiol. Biotechnol., 23, 168-173.






1985

Kell, D.B. & Harris, C.M. (1985) Dielectric spectroscopy and membrane organisation. J. Bioelectricity, 4, 317-348.

Kell, D.B. (1985) The electric microbe acid test [book review]. Trends Biotechnol. 3, 153-154.

Harris, C.M. & Kell, D.B. (1985) On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 2. Experiments with microbial cells, protoplasts and membrane vesicles. Eur. Biophys. J. 13, 11-24. Abstract.

Kell, D.B. & Harris, C.M. (1985) On the dielectrically observable consequences of the diffusional motions of lipids and proteins in membranes. 1. Theory and overview. Eur. Biophys. J. 12, 181-197. Abstract.

Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1985) Tinopal AN as a selective agent for the differentiation of phytopathogenic and saprophytic Pseudomonas species. J. Appl. Bacteriol. 58, 283-292.

Harris, C.M. & Kell, D.B. (1985) The estimation of microbial biomass. Biosensors J. 1, 17-84. Abstract.

Kell, D.B. (1985) Proton transport and cellular energetics. In: Proc. UNESCO Conference on Biophysical Correlates of Cellular Function (C.F. Hazlewood, ed.), pp. 52- 59. Houston.

Kell, D.B. & Westerhoff, H.V. (1985) Catalytic facilitation and membrane bioenergetics. In: Organized Multi-enzyme Systems: Catalytic Properties (G.R. Welch, ed.), pp. 63-139. Academic Press, New York.






1984

Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. & Kell, D.B. (1985) A minimal hypothesis for membrane-linked free-energy transduction: the role of independent, small coupling units. Biochim. Biophys. Acta 768, 257-292. Abstract. Hitchens, G.D. & Kell, D.B. (1984) On the effects of thiocyanate and venturicidin on respiration-driven proton translocation in Paracoccus denitrificans. Biochim. Biophys. Acta 766, 222-232. Abstract.

Kell, D.B. (1984) Constraints on the lateral diffusion of membrane proteins in prokaryotes. Trends Biochem. Sci. 9, 379.

Phillips, M.K., Rhodes-Roberts, M.E. & Kell, D.B. (1984) The anti-bacterial action of Tinopal AN. J. Gen. Microbiol. 130, 1999-2005. Abstract.

Kell, D.B. (1984) Diffusion of protein complexes in prokaryotic membranes: fast, free, random or directed? Trends Biochem. Sci. 9, 86-88.

Kell, D.B. (1984) Dielectric spectroscopy of the rotational and translational motions of membrane proteins: theory and experiment. EBEC Reports 3, 645-646.

Hitchens, G.D. & Kell, D.B. (1984) Effects of thiocyanate and venturicidin on respiration-driven H+ translocation in Paracoccus denitrificans. EBEC Reports 3, 243-244.

Kell, D.B. & Hitchens, G.D. (1984) Proton transfer pathways during bacterial electron transport phosphorylation. Biochem. Soc. Trans. 12, 413-414.

Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. & Kell, D.B. (1984) Mosaic protonic coupling hypothesis for free energy transduction. FEBS Lett. 165, 1-5.

Harris, C.M., Hitchens, G.D. & Kell, D.B. (1984) Dielectric properties of microbial membrane systems. In: Charge and Field Effects in Biosystems (M.J.Allen & P.N.R. Usherwood, eds.), pp. 179-185. Abacus Press, Tunbridge Wells.







1983

Kell, D.B. (1983) Coupling factor B and the bovine mitochondrial H+-ATP synthase. Trends Biochem. Sci. 8, 153-154.

Kell, D.B. (1983) Dielectric properties of bacterial chromatophores. Bioelectrochem. Bioenerg. 11, 405-415.

Melandri, B.A., Azzone, G.F., Kell, D.B., Venturoli, G. & Westerhoff, H.V. (1983) Is the transmembrane proton potential difference a competent intermediate in membrane- associated ATP synthesis? Proc. 6th Int. Congr. Photosynthesis, Brussels.

Keilmann, F. & Kell, D.B. (1983) Coherent excitation in biology. Nature 301, 656-657.

Harris, C.M. & Kell, D.B. (1983) The radio-frequency dielectric properties of yeast cells measured with a rapid, automated, frequency-domain dielectric spectrometer. Bioelectrochem. Bioenerg. 11, 15-28.

Kell, D.B. & Hitchens, G.D. (1983) Coherent properties of the membranous systems of electron transport phosphorylation. In: Coherent Excitations in Biological Systems (H. Fröhlich & F. Kremer, eds.), pp. 178-198. Springer, Berlin & Heidelberg.

Hitchens, G.D. & Kell, D.B. (1983) On the functional unit of energy coupling in photophosphorylation by bacterial chromatophores. Biochim. Biophys. Acta 723, 308-316. Hitchens, G.D. & Kell, D.B. (1982) Uncouplers can shuttle rapidly between localised energy coupling sites during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22. Biochem. J. 212, 25-30. Abstract.







1982

Phillips MK, Kell DB: A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEBS Lett 1982; 140:248-250.

Kell, D.B. & Hitchens, G.D. (1982) Proton-coupled energy transduction by biological membranes: principles, pathways and praxis. Disc. Faraday Soc. 74, 377-388.

Clarke, D.J., Kell, D.B., Morris, J.G. & Burns, A. (1982) The role of ion-selective electrodes in microbial process control. Ion-Selective Electrode Rev. 4, 75-131.

Kell, D.B. (1982) A rose by any other name. Trends Biochem. Sci 7, 420.

Kell, D.B. (1982) Enzymes as energy 'funnels'? Trends Biochem. Sci. 7, 349.

Kell, D.B. & Morris, J.G. (1982) On the role of interfacial water in protonmotive systems. In: Biophysics of Water (F. Franks & S.F. Mathias, eds.), pp. 137-139. Wiley, Chichester.

Hitchens, G.D. & Kell, D.B. (1982) Localised energy coupling during photophosphorylation by chromatophores of Rhodopseudomonas capsulata N22. Biosci. Rep. 2, 743-749. Abstract.

Kell, D.B. (1982) Bacteria that are resistant to uncouplers: what can they tell us? Trends Biochem. Sci. 7, 1-2.

Hitchens, G.D., Kell, D.B. & Morris, J.G. (1982) Transmembrane respiration-driven proton translocation is unimpaired in an eup mutant of Escherichia coli. J. Gen. Microbiol. 128, 2207-2209.

Hitchens, G.D. & Kell, D.B. (1982) Respiration-driven H+ translocation in Paracoccus denitrificans: role of the 'permeant' ion. Biochem. Soc. Trans. 10, 261.

Kell, D.B. & Hitchens, G.D. (1982) Respiration-driven proton translocation in Paracoccus denitrificans: role of the 'permeant' ion. EBEC Reports 2, 395-396.

Clarke, D.J., Morley, C.D., Kell, D.B. & Morris, J.G. (1982) On the mode of action of the bacteriocin butyricin 7423: effects on membrane potential and potassium ion accumulation in Clostridium pasteurianum. Eur. J. Biochem. 127, 105-116. Abstract.

Hitchens, G.D. & Kell, D.B. (1982) On the extent of localization of the energized membrane state in chromatophores from Rhodopseudomonas capsulata N22. Biochem. J. 206, 351-357. Abstract.

Phillips, M.K. & Kell, D.B. (1982) A novel inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEBS Lett. 140, 248- 250.






1981

Clarke, D.J., Kell, D.B., Morley, C.D. & Morris, J.G. (1981) Butyricin 7423 and the membrane H+-ATPase of Clostridium pasteurianum. Arch. Microbiol. 131, 81- 86. Abstract.

Kell, D.B. (1981) Are liposomes good models for biomembranes? Trends Biochem. Sci. 6, 8-9.

Vignais, P.M., Henry, M-F., Sim, E. & Kell, D.B. (1981) The electron transport system and hydrogenase of Paracoccus denitrificans. Curr. Top. Bioenerg. 12, 115- 196.

Kell, D.B. & Morris, J.G. (1981) Proton-coupled membrane energy trannsduction: pathways, mechanisms and control. In: Vectorial reactions in Electron and Ion Transport in Mitochondria and Bacteria (F. Palmieri, E. Quagliariello, N. Siliprandi & E.C. Slater, eds.), pp. 339-347. Elsevier/North Holland, Amsterdam.

Kell, D.B., Peck, M.W., Rodger, G. & Morris, J.G. (1981) On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridium pasteurianum. Biochem. Biophys. Res. Comm. 99, 81-88.

Phillips, M.K. & Kell, D.B. (1981) A benzoxazole inhibitor of NADH dehydrogenase in Paracoccus denitrificans. FEMS Microbiol. Lett. 11,111-113.

Kell, D.B., Doddema, H.J., Morris, J.G. & Vogels, G.D. (1981) Energy coupling in methanogens. In: Microbial Growth on C1 Compounds (H. Dalton, ed.) pp. 159-170. Heyden, London.

Clarke, D.J., White, N.J.M., Burns, A., Kell, D.B. & Morris, J.G. (1981) A flexible, microprocessor-directed fermentation system for the control of hardware and monitored parameters. Proc. 2nd Eur. Congr. Biotechnol. p. 145. Society for Chemical Industry, London.

Kell, D.B., Burns, A., Clarke, D.J. & Morris, J.G. (1981) Proteinaceous proton pumps: a minimal model, some properties and their possible universality. Specul. Sci. Technol. 4, 109-120.

Kell, D.B., Clarke, D.J. & Morris, J.G. (1981) On proton-coupled information transfer along the surface of biological membranes and the mode of action of certain colicins. FEMS Microbiol. Lett. 11, 1-11.

McCarthy, J.E.G., Ferguson, S.J. & Kell, D.B. (1981) Estimation with an ion-selective electrode of the membrane potential in cells of Paracoccus denitrificans from the uptake of the butyl triphenylphosphonium cation during aerobic and anaerobic respiration. Biochem. J. 196, 311-321. Abstract.

Smyth, M.R. & Kell, D.B. (1981) Polarographic investigation of some cytokinins. J. Electroanal. Chem. 122, 363-365.

Kell, D.B. & Griffiths, A.M. (1981) Polarographic assay of the binding of certain probe' molecules to bacteriorhodopsin sheets. Photobiochem. Photobiophys. 2, 105-110.






1980

Kell, D.B. & Morris, J.G. (1980) Formulation and some biological properties of a buffer mixture whose buffering capacity is relatively independent of pH in the range pH 4 to pH 9. J. Biochem. Biophys. Methods 3, 143-150. Abstract.

Doddema, H.J., Claesen, C.A., Kell, D.B., van der Drift, C. & Vogels, G.D. (1980) An adenine nucleotide translocase in the procaryote Methanobacterium thermoautotrophicum. Biochem. Biophys. Res. Comm. 95, 1288-1293.

Kell, D.B. & Griffiths, A.M. (1980) The 'energised state' in bacteriorhodopsin sheets. EBEC Reports 1, 423-424.

Kell, D.B. (1980) The optimisation of detector systems incorporating ion-selective electrodes. In: Electroanalysis in Hygiene, Environmental, Clinical and Pharaceutical Chemistry (W.F. Smyth, ed.), pp 61-77. Elsevier, Amsterdam.

Kell, D.B. (1980) The role of ion-selective electrodes in improving fermentation yields. Process Biochemistry 15(1), 18-23, 29.






1979

Kell, D.B. & Morris, J.G. (1979) Oxidation-reduction properties of coenzyme M (2- mercaptoethane sulphonate) at the mercury electrode. FEBS Lett. 108, 481-484.

Ferguson, S.J., Sorgato, M.C., Kell, D.B. & John, P. (1979) Comparative aspects of the energetics of oxidative phosphorylation in bacteria and mitochondria. Biochem. Soc. Trans. 7, 870-874.

Clarke, D.J., Kell, D.B. & Morris, J.G. (1979) The generation of a membrane potential by a fermentative bacterium. Biochem. Soc. Trans. 7, 1111-1112.

Ferguson, S.J., Jones, O.T.G., Kell, D.B. & Sorgato, M.C. (1979) Comparison of permeant ion uptake and carotenoid band shift as methods for determining the membrane potential in chromatophores from Rhodopseudomonas sphaeroides Ga. Biochem. J. 180, 75-85. Abstract.

Kell, D.B. (1979) On the functional proton current pathway of electron transport phosphorylation: an electrodic view. Biochim. Biophys. Acta 549, 55-99.

Ferguson, S.J., Gadian, D.G. & Kell, D.B. (1979) Evidence from 31P nuclear magnetic resonance that polyphosphate synthesis is a slip reaction in Paracoccus denitrificans. Biochem. Soc. Trans. 7, 176-179.






1978

Sorgato, M.C., Ferguson, S.J. & Kell, D.B. (1978) On the current-voltage relationships of energy-transducing membranes: submitochondrial particles. Biochem. Soc. Trans. 6, 1301- 1302.

Kell, D.B., John, P. & Ferguson, S.J. (1978) On the current- voltage relationships of energy-transducing membranes: phosphorylating membrane vesicles from Paracoccus denitrificans. Biochem. Soc. Trans. 6, 1292-1295.

Kell, D.B., Ferguson, S.J. & John, P. (1978) Measurement by a flow dialysis technique of the steady-state protonmotive force in chromatophores from Rhodospirillum rubrum: comparison with the phosphorylation potential. Biochim. Biophys. Acta 502, 111-126. Abstract.

Sorgato, M.C., Ferguson, S.J., Kell, D.B. & John, P. (1978) The protonmotive force in bovine heart submitochondrial particles: magnitude, sites of generation and comparison with the phosphorylation potential. Biochem. J. 174, 237-256. Abstract.

Kell, D.B., John, P. & Ferguson, S.J. (1978) The protonmotive force in phosphorylating membrane vesicles from Paracoccus denitrificans: magnitude, sites of generation and comparison with the phosphorylation potential. Biochem. J. 174, 257-266.

Ferguson, S.J., Kell, D.B. & John, P. (1978) Resolution of Paracoccus denitrificans vesicles of differing configuration using affinity chromatography. FEMS Microbiol. Lett. 3, 151-154.

Kell, D.B., John, P., Sorgato, M.C. & Ferguson, S.J. (1978) Continuous monitoring of the electrical potential across energy- transducing membranes using ion-selective electrodes: application to submitochondrial particles and chromatophores. FEBS Lett. 86, 294-298.






1977

Kell, D.B. & John, P. (1977) Studying mitochondria by using bacteria. ATLA Abstracts 5, 10-11.





White Papers

Occasionally we are asked (or choose) to produce position statements on various scientific topics. This section provides access to some of them.

Puplications

Kell, D.B. & Mendes, P. (1999) Snapshots of systems - metabolic control analysis and biotechnology in the post-genomic era. In Technological and Medical Implications of Metabolic Control Analysis (A. Cornish-Bowden and M.L.Cárdenas, ed.) pp. 3-25. Kluwer Academic Publishers, Dordrecht. Ms available in Postscript or pdf versions. See also a draft (pre-meeting) web version.

Knowles, J. & Corne, D. (2004) Memetic Algorithms for Multiobjective Optimization: Issues, Methods and Prospects. In Recent Advances in Memetic Algorithms. Krasnogor, N., Smith, J.E., and Hart, W.E. (eds). Springer (to appear Autumn 2004).

Handl, J. & Knowles, J. (2004) Evolutionary multiobjective clustering. In Parallel Problem Solving from Nature, (PPSN VIII). Springer (to appear September 2004).

Presentations

Jones, A. (1996) An Introduction to Multivariate Calibration. Institute of Biological Sciences, University of Wales, Aberystwyth, Dyfed SY23 3DA.



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